Evidence map›Paper›PMID 33185468›Full record

Trial reportJournal of child and adolescent psychopharmacology2020

A Phase 3, Randomized Double-Blind Study of the Efficacy and Safety of Low-Dose SHP465 Mixed Amphetamine Salts Extended-Release in Children with Attention-Deficit/Hyperactivity Disorder.

Greg Mattingly, Valerie Arnold, Brian Yan, Ming Yu, Brigitte Robertson

Abstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child and adolescent psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of amphetamines on blood pressure.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Greg MattinglyMidwest Research Group, St. Charles, Missouri, USA.
Valerie ArnoldCNS Healthcare, Memphis, Tennessee, USA.
Brian YanBiostatistics, Shire, a Member of the Takeda Group of Companies, Lexington, Massachusetts, USA.
Ming YuGlobal Clinical Development, Shire, a Member of the Takeda Group of Companies, Lexington, Massachusetts, USA.
Brigitte RobertsonGlobal Clinical Development, Shire, a Member of the Takeda Group of Companies, Lexington, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Treatment OutcomeAmphetamineAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildDelayed-Action PreparationsDouble-Blind MethodFemaleHeadacheHumansMaleSaltsAmphetamineCentral Nervous System StimulantsDelayed-Action PreparationsSaltsattention-deficit/hyperactivity disorder (ADHD)childrenefficacysafety and tolerabilitySHP465 (Mydayis) mixed amphetamine salts

Identifiers

PMID33185468
PMCPMC7698843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.