ArticleThe EMBO journal2021
Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport.
Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 108 citations in OpenAlex.
- Subspecies-specific metabolic gene clusters shape polyphenol dynamics for modular metabolic breeding in sugarcane.Plant communications · 2026Article
- Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root.The Plant cell · 2026Article
- Genome-Wide Identification of the PIN-LIKES (Current issues in molecular biology · 2026Article
- SMXL3 controls multiple aspects of Arabidopsis development via EAR motif-dependent and -independent functions.The Plant journal : for cell and molecular biology · 2026Article
- Screening olour mango half-sib progenies for dwarfing, vigour, and climate resilience.Scientific reports · 2025Article
- Analysis of changes and biosynthesis mechanism of flavonoids in Peel of Coffea Arabica L. during ripening based on metabolome and transcriptome.BMC genomics · 2025Article
- Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude inLife science alliance · 2025Article
- Alterations in carbon and nitrogen metabolism under phenylalanine ammonia-lyase inhibition in winter triticale seedlings.Scientific reports · 2025Article
- Tomato pollen tube growth requires flavonol glycosylation.Plant physiology · 2025Article
- A Comprehensive Review of Phenolic Compounds in Horticultural Plants.International journal of molecular sciences · 2025Review
- Biosynthesis and Regulatory Mechanisms of Plant Flavonoids: A Review.Plants (Basel, Switzerland) · 2025Review
- Biosynthesis and Physiological Significance of Organ-Specific Flavonol Glycosides in Solanaceae.bioRxiv : the preprint server for biology · 2025Article
- Creeping Stem 1 regulates directional auxin transport for lodging resistance in soybean.Plant biotechnology journal · 2025Article
- The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.Frontiers in plant science · 2025Article
- Gravacin as an inhibitor of the auxin transport-activating protein kinase D6PK inFrontiers in plant science · 2025Article
- Antioxidants by nature: an ancient feature at the heart of flavonoids' multifunctionality.The New phytologist · 2025Article
- Over 25 years of decrypting PIN-mediated plant development.Nature communications · 2024Review
- Dissecting the Herbicidal Mechanism of Microbial Natural Product Lydicamycins Using a Deep Learning-Based Nonlinear Regression Model.ACS omega · 2024Article
- Small peptide SiDVL/RTFLs from foxtail millet inhibit root growth through repressing auxin signaling in transgenic Arabidopsis.Plant cell reports · 2024Article
- Identification of tomato F-box proteins functioning in phenylpropanoid metabolism.Plant molecular biology · 2024Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 5 countries.
Funding
Abstract
The transport of auxin controls the rate, direction and localization of plant growth and development. The course of auxin transport is defined by the polar subcellular localization of the PIN proteins, a family of auxin efflux transporters. However, little is known about the composition and regulation of the PIN protein complex. Here, using blue-native PAGE and quantitative mass spectrometry, we identify native PIN core transport units as homo- and heteromers assembled from PIN1, PIN2, PIN3, PIN4 and PIN7 subunits only. Furthermore, we show that endogenous flavonols stabilize PIN dimers to regulate auxin efflux in the same way as does the auxin transport inhibitor 1-naphthylphthalamic acid (NPA). This inhibitory mechanism is counteracted both by the natural auxin indole-3-acetic acid and by phosphomimetic amino acids introduced into the PIN1 cytoplasmic domain. Our results lend mechanistic insights into an endogenous control mechanism which regulates PIN function and opens the way for a deeper understanding of the protein environment and regulation of the polar auxin transport complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.