Evidence map›Paper›PMID 33185192›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2021

Fetal brain growth and risk of postnatal white matter injury in critical congenital heart disease.

Shabnam Peyvandi, Jessie Mei Lim, Davide Marini, Duan Xu, V Mohan Reddy, A James Barkovich, Steven Miller, Patrick McQuillen, Mike Seed

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
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  10. Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2024
    Article
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  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shabnam PeyvandiDepartment of Pediatrics, University of California San Francisco, Benioff Children's Hospital, San Francisco, Calif. Electronic address: shabnam.peyvandi@ucsf.edu.
Jessie Mei LimDepartment of Pediatrics, University of Toronto Hospital for Sick Children, Toronto, Ontario, Canada.
Davide MariniDepartment of Pediatrics, University of Toronto Hospital for Sick Children, Toronto, Ontario, Canada.
Duan XuDepartment of Radiology, University of California San Francisco, Benioff Children's Hospital, San Francisco, Calif.
V Mohan ReddyDepartment of Surgery, University of California San Francisco, Benioff Children's Hospital, San Francisco, Calif.
A James BarkovichDepartment of Radiology, University of California San Francisco, Benioff Children's Hospital, San Francisco, Calif.
Steven MillerDepartment of Neurology, University of Toronto Hospital for Sick Children, Toronto, Ontario, Canada.
Patrick McQuillenDepartment of Pediatrics, University of California San Francisco, Benioff Children's Hospital, San Francisco, Calif.
Mike SeedDepartment of Pediatrics, University of Toronto Hospital for Sick Children, Toronto, Ontario, Canada.

Funding

Repair in High Risk Newborns with Congential Heart DiseaseP01NS082330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XU, DUAN · 2014 to 2018
$6.0M
Development of Advanced Techniques for MR of the Newborn BrainR01EB009756 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARKOVICH, ANTHONY JAMES, XU, DUAN · 2009 to 2013
$5.5M
3D MR SPECTROSCOPIC IMAGING OF THE NEWBORN BRAINR01NS040117 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI VIGNERON, DANIEL B · 2001 to 2005
$1.9M
Fetal markers of neurodevelopmental outcomes in congenital heart diseaseK23NS099422 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PEYVANDI, SHABNAM · 2017 to 2021
$961k
White Matter Injury in Critical Ill Newborns With Congenital Heart DiseaseR01NS063876 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN · 2009 to 2010
$833k
NIBIB NIH HHS R01 EB009756NINDS NIH HHS K23 NS099422NINDS NIH HHS P01 NS082330NINDS NIH HHS R01 NS040117NINDS NIH HHS R01 NS063876
6 · The paper itself

Abstract

objectiveTo test the hypothesis that delayed brain development in fetuses with d-transposition of the great arteries or hypoplastic left heart syndrome heightens their postnatal susceptibility to acquired white matter injury.

methodsThis is a cohort study across 3 sites. Subjects underwent fetal (third trimester) and neonatal preoperative magnetic resonance imaging of the brain to measure total brain volume as a measure of brain maturity and the presence of acquired white matter injury after birth. White matter injury was categorized as no-mild or moderate-severe based on validated grading criteria. Comparisons were made between the injury groups.

resultsA total of 63 subjects were enrolled (d-transposition of the great arteries: 37; hypoplastic left heart syndrome: 26). White matter injury was present in 32.4% (n = 12) of d-transposition of the great arteries and 34.6% (n = 8) of those with hypoplastic left heart syndrome. Overall total brain volume (taking into account fetal and neonatal scan) was significantly lower in those with postnatal moderate-severe white matter injury compared with no-mild white matter injury after adjusting for age at scan and site in d-transposition of the great arteries (coefficient: 14.8 mL, 95% confidence interval, -28.8 to -0.73, P = .04). The rate of change in total brain volume from fetal to postnatal life did not differ by injury group. In hypoplastic left heart syndrome, no association was noted between overall total brain volume and change in total brain volume with postnatal white matter injury.

conclusionsLower total brain volume beginning in late gestation is associated with increased risk of postnatal moderate-severe white matter injury in d-transposition of the great arteries but not hypoplastic left heart syndrome. Rate of brain growth was not a risk factor for white matter injury. The underlying fetal and perinatal physiology has different implications for postnatal risk of white matter injury.

Indexed as

BrainCanadaFemaleFetal DevelopmentGestational AgeHumansHypoplastic Left Heart SyndromeInfant, NewbornLeukoencephalopathiesLongitudinal StudiesMagnetic Resonance ImagingMaleOrgan SizePregnancyPrenatal DiagnosisProspective Studiesbrain developmentbrain injurycongenital heart diseaseneurodevelopment

Identifiers

PMID33185192
PMCPMC8012393

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.