Evidence map›Paper›PMID 33185112›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2021

Morning sympathetic activity after evening binge alcohol consumption.

Ian M Greenlund, Hannah A Cunningham, Anne L Tikkanen, Jeremy A Bigalke, Carl A Smoot, John J Durocher, Jason R Carter

Erratum issuedOpen access · greenAbstract readPragmatic Clinical TrialRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Cardiovascular and aortic wave reflection responses to evening binge alcohol consumption.American journal of physiology. Heart and circulatory physiology · 2025
    Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Actigraphy-based sleep and muscle sympathetic nerve activity in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  10. Review
  11. Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Taking to "heart" the proposed legislation for permanent daylight saving time.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  16. Reliability of heart rate variability during stable and disrupted polysomnographic sleep.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  17. Article
  18. Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  19. Article
  20. Blunted heart rate recovery to spontaneous nocturnal arousals in short-sleeping adults.American journal of physiology. Heart and circulatory physiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ian M GreenlundDepartment of Psychology, Montana State University, Bozeman, Montana.
Hannah A CunninghamDepartment of Health and Human Development, Montana State University, Bozeman, Montana.
Anne L TikkanenDepartment of Health and Human Development, Montana State University, Bozeman, Montana.
Jeremy A BigalkeDepartment of Psychology, Montana State University, Bozeman, Montana.
Carl A SmootDepartment of Health and Human Development, Montana State University, Bozeman, Montana.
John J DurocherDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan.
Jason R CarterDepartment of Health and Human Development, Montana State University, Bozeman, Montana.
Michigan Technological University · USMontana State University · USPurdue University Northwest · US

Funding

Alcohol and Neurovascular Control in HumansR01AA024892 · NIAAA · MONTANA STATE UNIVERSITY - BOZEMAN · PI CARTER, JASON R · 2017 to 2021
$1.8M
HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAA) AA024892NIAAA NIH HHS R01 AA024892
6 · The paper itself

Abstract

Binge alcohol consumption elicits acute and robust increases of muscle sympathetic nerve activity (MSNA), yet the impact of evening binge drinking on morning-after MSNA is unknown. The present study examined the effects of evening binge alcohol consumption on polysomnographic sleep and morning-after MSNA. We hypothesized that evening binge drinking (i.e. 4-5 drink equivalent in <2 h) would reduce sleep quality and increase morning-after blood pressure (BP) and MSNA. Following a familiarization night within the sleep laboratory, 22 participants (12 men, 10 women; 25 ± 1 yr) were examined after simulated binge drinking or fluid control (randomized, crossover design). Morning MSNA was successfully recorded across both conditions in 16 participants (8 men, 8 women) during a 10-min baseline and three Valsalva's maneuvers (VM). Binge drinking reduced rapid eye movement (REM) sleep (15 ± 1 vs. 20 ± 1%,

Indexed as

Circadian RhythmAdultBaroreflexBinge DrinkingBlood PressureCardiovascular SystemCross-Over StudiesFemaleHeart RateHumansMaleMuscle, SkeletalSleep, REMSympathetic Nervous SystemTime FactorsUrinationautonomic activitybaroreflex sensitivityethanolhypertensionsleep

Identifiers

PMID33185112
PMCPMC7864252
OpenAlexW3101124041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.