Evidence map›Paper›PMID 33185092›Full record

ArticleEnvironmental science & technology2020

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study.

Christopher D Kassotis, Nicholas J Herkert, Stephanie C Hammel, Kate Hoffman, Qianyi Xia, Seth W Kullman, Julie Ann Sosa, Heather M Stapleton

Abstract read
In one paragraph

Article in Environmental science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Silicone Wristbands for Measuring Human Exposure to Organic Chemicals: Uses and Benefits for Human Biological Research.American journal of human biology : the official journal of the Human Biology Council · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christopher D KassotisNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-0990-2428
Nicholas J HerkertNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-3286-8934
Stephanie C HammelNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0001-5334-2045
Kate HoffmanNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0001-8029-7710
Qianyi XiaNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.
Seth W KullmanToxicology Program, North Carolina State University, Raleigh, North Carolina 27695, United States.
Julie Ann SosaDepartment of Surgery, University of California at San Francisco, San Francisco, California 94143, United States.
Heather M StapletonNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-9995-6517

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
Novel Analytical and Experimental Approaches for Predicting the Biological Effects of MixturesR01ES027813 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEBSTER, THOMAS F · 2017 to 2021
$2.2M
Development and Testing of Response Surface Methods for Investigating the Epidemiology of Exposure to MixturesR01ES028800 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEBSTER, THOMAS F · 2018 to 2021
$1.7M
Mechanisms of Environmental-Mixture Induced Metabolic DisruptionR00ES030405 · NIEHS · WAYNE STATE UNIVERSITY · PI KASSOTIS, CHRISTOPHER DENNIS · 2020 to 2022
$744k
Mechanisms of Environmental-Mixture Induced Metabolic DisruptionK99ES030405 · NIEHS · DUKE UNIVERSITY · PI KASSOTIS, CHRISTOPHER DENNIS · 2019 to 2020
$199k
Interrogation of molecular mechanisms involved in driving adipogenesis in environmental mixtures and novel analytical techniques for identifying putative causative chemicalsF32ES027320 · NIEHS · DUKE UNIVERSITY · PI KASSOTIS, CHRISTOPHER DENNIS · 2017 to 2018
$117k
NIEHS NIH HHS F32 ES027320NIEHS NIH HHS K99 ES030405NIEHS NIH HHS P42 ES010356NIEHS NIH HHS R00 ES030405NIEHS NIH HHS R01 ES016099NIEHS NIH HHS R01 ES027813NIEHS NIH HHS R01 ES028800
6 · The paper itself

Abstract

Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chemical mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chemical mixtures extracted from wristbands (

Indexed as

Flame RetardantsThyroid NeoplasmsAdultAntithyroid AgentsCase-Control StudiesEnvironmental MonitoringHalogenated Diphenyl EthersHEK293 CellsHumansNorth CarolinaPilot ProjectsProspective StudiesSiliconesThyroid Cancer, PapillaryAntithyroid AgentsFlame RetardantsHalogenated Diphenyl EthersSilicones

Identifiers

PMID33185092
PMCPMC7819617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.