Evidence map›Paper›PMID 33185016›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2021

Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID-19.

Joht Singh Chandan, Dawit Tefra Zemedikun, Rasiah Thayakaran, Nathan Byne, Samir Dhalla, Dionisio Acosta-Mena, Krishna M Gokhale, Tom Thomas, Christopher Sainsbury, Anuradhaa Subramanian and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Sex differences among users of NSAIDs and opioids during COVID-19 Pandemic.International journal of clinical pharmacy · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Effect of the Duration of NSAID Use on COVID-19.Medicina (Kaunas, Lithuania) · 2022
    Observational
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 2 countries.

Joht Singh ChandanInstitute of Applied Health Research, University of Birmingham, Birmingham, UK, and Warwick Medical School, University of Warwick, Coventry, UK.ORCID 0000-0002-9561-5141
Dawit Tefra ZemedikunInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Rasiah ThayakaranInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Nathan ByneCegedim Rx, London, UK.
Samir DhallaCegedim Rx, London, UK.
Dionisio Acosta-MenaCegedim Rx, London, UK.
Krishna M GokhaleInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Tom ThomasKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID 0000-0002-2188-3784
Christopher SainsburyInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Anuradhaa SubramanianInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Jennifer CooperInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Astha AnandInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Kelvin O OkothInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Jingya WangInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Nicola J AdderleyInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Thomas TavernerInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Alastair K DennistonInstitute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Janet LordInstitute of Inflammation and Ageing, University of Birmingham, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK.
G Neil ThomasInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Christopher D BuckleyKennedy Institute of Rheumatology, University of Oxford, Oxford, UK, and Institute of Inflammation and Ageing, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK.
Karim RazaInstitute of Inflammation and Ageing, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Sandwell and West Birmingham NHS Hospitals Trust, Birmingham, UK.
Neeraj BhalaInstitute of Applied Health Research, University of Birmingham, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Krishnarajah NirantharakumarInstitute of Applied Health Research, University of Birmingham, Health Data Research UK Midlands, Birmingham, UK.
Shamil HaroonInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
University of Birmingham · GBCegedim (France) · FRArthritis UK · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Oxford · GBHealth Data Research UK · GBUniversity of Warwick · GB

Funding

Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1Medical Research Council MR/S003878/1
6 · The paper itself

Abstract

objectiveTo identify whether active use of nonsteroidal antiinflammatory drugs (NSAIDs) increases susceptibility to developing suspected or confirmed coronavirus disease 2019 (COVID-19) compared to the use of other common analgesics.

methodsWe performed a propensity score-matched cohort study with active comparators, using a large UK primary care data set. The cohort consisted of adult patients age ≥18 years with osteoarthritis (OA) who were followed up from January 30 to July 31, 2020. Patients prescribed an NSAID (excluding topical preparations) were compared to those prescribed either co-codamol (paracetamol and codeine) or co-dydramol (paracetamol and dihydrocodeine). A total of 13,202 patients prescribed NSAIDs were identified, compared to 12,457 patients prescribed the comparator drugs. The primary outcome measure was the documentation of suspected or confirmed COVID-19, and the secondary outcome measure was all-cause mortality.

resultsDuring follow-up, the incidence rates of suspected/confirmed COVID-19 were 15.4 and 19.9 per 1,000 person-years in the NSAID-exposed group and comparator group, respectively. Adjusted hazard ratios for suspected or confirmed COVID-19 among the unmatched and propensity score-matched OA cohorts, using data from clinical consultations in primary care settings, were 0.82 (95% confidence interval [95% CI] 0.62-1.10) and 0.79 (95% CI 0.57-1.11), respectively, and adjusted hazard ratios for the risk of all-cause mortality were 0.97 (95% CI 0.75-1.27) and 0.85 (95% CI 0.61-1.20), respectively. There was no effect modification by age or sex.

conclusionNo increase in the risk of suspected or confirmed COVID-19 or mortality was observed among patients with OA in a primary care setting who were prescribed NSAIDs as compared to those who received comparator drugs. These results are reassuring and suggest that in the absence of acute illness, NSAIDs can be safely prescribed during the ongoing pandemic.

Indexed as

MortalityAcetaminophenAdultAgedAged, 80 and overAnalgesicsAnti-Inflammatory Agents, Non-SteroidalCase-Control StudiesCause of DeathCodeineCOVID-19Disease SusceptibilityDrug CombinationsFemaleHumansIncidenceAcetaminophenacetaminophen, codeine drug combinationAnalgesicsAnti-Inflammatory Agents, Non-SteroidalCodeinedihydrocodeineDrug Combinations

Identifiers

PMID33185016
PMCPMC8252419
OpenAlexW3099769602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.