Evidence map›Paper›PMID 33184872›Full record

ReviewAnnals of the New York Academy of Sciences2020

Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus.

Hiroshi Mashimo, Stuart R Gordon, Satish K Singh

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hiroshi MashimoVA Boston Healthcare System, Boston, Massachusetts.ORCID 0000-0002-6132-6771
Stuart R GordonDartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, New Hampshire.
Satish K SinghVA Boston Healthcare System, Boston, Massachusetts.

Funding

OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHYR01CA075289 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FUJIMOTO, JAMES G, MASHIMO, HIROSHI · 1997 to 2018
$4.8M
Omniview tethered capsule for low cost, non-endoscopic Barrett's esophagus screening in unsedated patientsR01CA252216 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FUJIMOTO, JAMES G · 2020 to 2022
$1.0M
CMA: Marker-assisted prevention and risk stratification (MAPRS): Artificial Intelligence Endoscopy for Colorectal Cancer Prevention (CMA1)I01BX004455 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SINGH, SATISH K · 2019 to 2022
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Optical Spectroscopy in the Management of Colorectal NeoplasiaI01CX001146 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SINGH, SATISH K · 2015 to 2023
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BLRD VA I01 BX004455CSRD VA I01 CX001146NCI NIH HHS R01 CA075289NCI NIH HHS R01 CA252216
6 · The paper itself

Abstract

Esophageal cancers, largely adenocarcinoma in Western countries and squamous cell cancer in Asia, present a significant burden of disease and remain one of the most lethal of cancers. Key to improving survival is the development and adoption of new imaging modalities to identify early neoplastic lesions, which may be small, multifocal, subsurface, and difficult to detect by standard endoscopy. Such advanced imaging is particularly relevant with the emergence of ablative techniques that often require multiple endoscopic sessions and may be complicated by bleeding, pain, strictures, and recurrences. Assessing the specific location, depth of involvement, and features correlated with neoplastic progression or incomplete treatment may optimize treatments. While not comprehensive of all endoscopic imaging modalities, we review here some of the recent advances in endoscopic luminal imaging, particularly with surface contrast enhancement using virtual chromoendoscopy, highly magnified subsurface imaging with confocal endomicroscopy, optical coherence tomography, elastic scattering spectroscopy, angle-resolved low-coherence interferometry, and light scattering spectroscopy. While there is no single ideal imaging modality, various multimodal instruments are also being investigated. The future of combining computer-aided assessments, molecular markers, and improved imaging technologies to help localize and ablate early neoplastic lesions shed hope for improved disease outcome.

Indexed as

AdenocarcinomaEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagoscopyEsophagusHumansMicroscopy, ConfocalTomography, Optical CoherenceBarrett's esophaguscomputer-aided diagnosisconfocal laser endomicroscopyesophageal cancernarrowband imagingoptical coherence tomography

Identifiers

PMID33184872
PMCPMC7780427

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.