ArticleNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2021
Sonothrombolysis in the ambulance for ST-elevation myocardial infarction: rationale and protocol.
Article in Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Role of Ultrasound-Based Therapies in Cardiovascular Diseases.Structural heart : the journal of the Heart Team · 2025Review
- Sono-assisted-thrombolysis by three-dimensional diagnostic ultrasound improves epicardial recanalization and microvascular perfusion in acute myocardial infarction.Quantitative imaging in medicine and surgery · 2022Article
- Feasibility of sonothrombolysis in the ambulance for ST-elevation myocardial infarction.The international journal of cardiovascular imaging · 2022Article
- Contrast Ultrasound, Sonothrombolysis and Sonoperfusion in Cardiovascular Disease: Shifting to Theragnostic Clinical Trials.JACC. Cardiovascular imaging · 2022Review
- Assessment and Treatment for Coronary Microvascular Dysfunction by Contrast Enhanced Ultrasound.Frontiers in cardiovascular medicine · 2022Review
- Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist.Pediatric radiology · 2021Review
- New Interventional Therapies beyond Stenting to Treat ST-Segment Elevation Acute Myocardial Infarction.Journal of cardiovascular development and disease · 2021Review
- Advances in Ultrasound Therapeutics.Current cardiology reports · 2021Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of ST-elevation myocardial infarction (STEMI) has improved over the years. Current challenges in the management of STEMI are achievement of early reperfusion and the prevention of microvascular injury. Sonothrombolysis has emerged as a potential treatment for acute myocardial infarction, both for epicardial recanalisation as well as improving microvascular perfusion. This study aims to determine safety and feasibility of sonothrombolysis application in STEMI patients in the ambulance.
methodsTen patients with STEMI will be included and treated with sonothrombolysis in the ambulance during transfer to the PCI centre. Safety will be assessed by the occurrence of ventricular arrhythmias and shock during sonothrombolysis intervention. Feasibility will be assessed by the extent of protocol completion and myocardial visibility. Efficacy will be determined by angiographic patency rate, ST-elevation resolution, infarct size and left ventricular volumes, and function measured with cardiovascular magnetic resonance imaging, and contrast and strain echocardiography. A comparison will be made with matched controls using an existing STEMI database. DISCUSSION: Sonothrombolysis is a novel technique for the treatment of cardiovascular thromboembolic disease. The first clinical trials on its use for STEMI have demonstrated promising results. This study will be the first to examine the feasibility of in-ambulance sonothrombolysis for STEMI.
trial registrationEU Clinical Trials Register (identifier: 2019-001883-31), registered 2020-02-25.
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