Evidence map›Paper›PMID 33184751›Full record

ArticleTransgenic research2020

Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.

Priyadarshan Kinatukara, Purnima Sailasree Subramaniyan, Gajanan S Patil, Sakshi Shambhavi, Shubham Singh, Amol Mhetre, Murali Krishna Madduri, Avinash Soundararajan, Ketan D Patel, P Chandra Shekar and 3 more

Abstract read
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In one paragraph

Article in Transgenic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Transcriptomic profiling ofComputational and structural biotechnology journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Priyadarshan KinatukaraCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.ORCID 0000-0003-2210-2369
Purnima Sailasree SubramaniyanCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.
Gajanan S PatilCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.ORCID 0000-0003-0562-3584
Sakshi ShambhaviCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.ORCID 0000-0002-8852-1542
Shubham SinghDepartment of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India.
Amol MhetreDepartment of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India.
Murali Krishna MadduriCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.
Avinash SoundararajanCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.
Ketan D PatelCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.
P Chandra ShekarCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.
Siddhesh S KamatDepartment of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India.ORCID 0000-0001-6132-7574
Satish KumarCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India. satishk.scientist@gmail.com.
Rajan SankaranarayananCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India. sankar@ccmb.res.in.ORCID 0000-0003-4524-9953
Centre for Cellular and Molecular Biology · INIndian Institute of Science Education and Research Pune · IN

Funding

The Wellcome Trust DBT India Alliance IA/I/15/2/502058
6 · The paper itself

Abstract

Disco-interacting protein 2 is a highly conserved three-domain protein with two tandem Adenylate-forming domains. It is proposed to influence the processes involved in neuronal development by influencing lipid metabolism and remains to be characterized. In this study, we show that Disco-interacting protein 2a null mice do not exhibit overt phenotype defects. However, the body composition differences were observed in these mice under different dietary regimens. The neutral lipid composition of two different diets was characterized, and it was observed that the new-born mice grow relatively slower than the wild-type mice with delayed appearance of features such as dentition when fed with high-triacylglycerol NIN-formulation diet. The high-diacylglycerol Safe-formulation diet was found to accumulate more fat mass in mice than those fed with high-triacylglycerol NIN-formulation diet beyond 10 months. These findings point to a proposed relationship between dietary components (particularly the lipid composition) and body composition along with the growth of neonates in mice lacking the gene Disco-interacting protein 2a.

Indexed as

Adipose TissueAnimal FeedAnimalsAnimals, NewbornBody CompositionDietDiglyceridesFemaleMaleMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutNuclear ProteinsObesityTriglyceridesDiglyceridesDip2a protein, mouseNuclear ProteinsTriglyceridesAdenylate-forming domainsDietary componentsDisco-interacting protein 2Lipid composition

Identifiers

PMID33184751
OpenAlexW3098554907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.