Evidence map›Paper›PMID 33184721›Full record

ArticleJournal of clinical immunology2021

Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling.

Kelsey Kaman, Monique Abrams, Kerry Dobbs, Luigi D Notarangelo, Ottavia M Delmonte, Boaz Palterer, Sung-Yun Pai, Alicia Johnston

Open access · greenAbstract readCase ReportsLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. A boy with a novel homozygous ZAP70 mutation presenting with a dermatological phenotype and postnatal decrease in CD8Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Kelsey KamanDepartment of Pediatrics, UMMS-Baystate, Springfield, MA, USA. kelseykaman@gmail.com.ORCID 0000-0001-9705-5312
Monique AbramsDepartment of Pediatrics, UMMS-Baystate, Springfield, MA, USA.
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Boaz PaltererDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Sung-Yun PaiDivision of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.
Alicia JohnstonDepartment of Pediatrics, UMMS-Baystate, Springfield, MA, USA.
National Institutes of Health · USBaystate Health · USAzienda Ospedaliero-Universitaria Careggi · ITBaystate Medical Center · USBoston Children's Hospital · US

Funding

Characterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2M
Intramural NIH HHS ZIA AI001222
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

FemaleHeterozygoteHumansInfantMutationPhenotypeReceptors, Antigen, T-CellSevere Combined ImmunodeficiencySignal TransductionZAP-70 Protein-Tyrosine KinaseReceptors, Antigen, T-CellZAP70 protein, humanZAP-70 Protein-Tyrosine Kinase

Identifiers

PMID33184721
PMCPMC8319789
OpenAlexW3104820732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.