Evidence map›Paper›PMID 33184509›Full record

ArticleNature medicine2021

Characterization of pre-existing and induced SARS-CoV-2-specific CD8

Isabel Schulien, Janine Kemming, Valerie Oberhardt, Katharina Wild, Lea M Seidel, Saskia Killmer, Sagar, Franziska Daul, Marilyn Salvat Lago, Annegrit Decker and 22 more

Open access · bronzeAbstract read
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In one paragraph

Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 1 synthesis or guideline pooled it, 397 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  5. Review
  6. Article
  7. Distinct CD8iScience · 2026
    Article
  8. Article
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  14. Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
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200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 4 institutions in 2 countries.

Isabel Schulien *Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Janine Kemming *Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Valerie Oberhardt *Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Katharina Wild *Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Lea M Seidel *Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Saskia Killmer *Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
SagarMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Franziska DaulDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marilyn Salvat LagoDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Annegrit DeckerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Hendrik LuxenburgerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-7182-8620
Benedikt BinderDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Dominik BettingerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-8782-8729
Oezlem SogukpinarDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Siegbert RiegDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marcus PanningInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Daniela HuzlyInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Martin SchwemmleInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-2972-6855
Georg KochsInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Cornelius F WallerDepartment of Haematology, Oncology & Stem Cell Transplantation, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-5777-0212
Alexandra NietersCenter for Biobanking-FREEZE-Biobanking, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Daniel DuerschmiedDepartment of Medicine III (Interdisciplinary Medical Intensive Care), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-5249-4012
Florian EmmerichInstitute for Transfusion Medicine and Gene Therapy, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Henrik E MeiGerman Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.ORCID http://orcid.org/0000-0003-0697-7755
Axel Ronald SchulzGerman Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.ORCID http://orcid.org/0000-0002-5106-0148
Sian Llewellyn-LaceyDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0001-9416-2737
Tobias BoettlerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-1195-055X
Bertram BengschDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-2552-740X
Robert ThimmeDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. robert.thimme@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0003-1417-4135
Maike HofmannDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. maike.hofmann@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0001-8410-8833
Christoph Neumann-HaefelinDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. christoph.neumann-haefelin@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0001-7351-1387
University of Freiburg · DECardiff University · GBGerman Rheumatism Research Centre · DEMax Planck Institute of Immunobiology and Epigenetics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging data indicate that SARS-CoV-2-specific CD8

Indexed as

Case-Control StudiesCD8-Positive T-LymphocytesConvalescenceCoronavirus Nucleocapsid ProteinsCOVID-19Cross ReactionsCross-Sectional StudiesEpitopes, T-LymphocyteFlow CytometryHLA-B AntigensHumansImmunologic MemoryLongitudinal StudiesPhosphoproteinsSARS-CoV-2Spike Glycoprotein, CoronavirusCoronavirus Nucleocapsid ProteinsEpitopes, T-LymphocyteHLA-B Antigensnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID33184509
OpenAlexW3099293845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.