Evidence map›Paper›PMID 33184477›Full record

ArticleMucosal immunology2021

Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation.

Valentina Ugalde, Francisco Contreras, Carolina Prado, Ornella Chovar, Alexandra Espinoza, Rodrigo Pacheco

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Impact of oralmSystems · 2025
    Article
  5. Article
  6. Dopaminergic signalling in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Anti-Inflammatory Effects of Peripheral Dopamine.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Valentina UgaldeLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, 7780272, Ñuñoa, Santiago, Chile.
Francisco ContrerasLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, 7780272, Ñuñoa, Santiago, Chile.
Carolina PradoLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, 7780272, Ñuñoa, Santiago, Chile.
Ornella ChovarLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, 7780272, Ñuñoa, Santiago, Chile.
Alexandra EspinozaLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, 7780272, Ñuñoa, Santiago, Chile.
Rodrigo PachecoLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, 7780272, Ñuñoa, Santiago, Chile. rpacheco@cienciavida.org.ORCID http://orcid.org/0000-0001-8057-9806
Fundación Ciencia and Vida · CLSan Sebastián University · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence from inflammatory bowel diseases (IBD) patients and animal models has indicated that gut inflammation is driven by effector CD4

Indexed as

AnimalsCells, CulturedColitisDisease Models, AnimalDopaminergic NeuronsHumansImmunosuppression TherapyInflammationInflammatory Bowel DiseasesInterleukin-10IntestinesMiceMice, Inbred C57BLMice, KnockoutNeuroimmunomodulationReceptors, Dopamine D3Interleukin-10Receptors, Dopamine D3Receptors, Lymphocyte HomingRNA, Small Interfering

Identifiers

PMID33184477
OpenAlexW3101086311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.