Evidence map›Paper›PMID 33184469›Full record

ReviewNature reviews. Neuroscience2021

Encouraging an excitable brain state: mechanisms of brain repair in stroke.

Mary T Joy, S Thomas Carmichael

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 7 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 7 syntheses or guidelines pooled it, 259 citations in OpenAlex.

  1. Pooled it
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  6. Guideline
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  19. Benefits and Importance of Early Rehabilitation in Patients After Stroke.Journal of functional morphology and kinesiology · 2026
    Review
  20. Review

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mary T JoyDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
S Thomas CarmichaelDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. SCarmichael@mednet.ucla.edu.ORCID 0000-0002-1169-9203
University of California, Los Angeles · US

Funding

Mechanisms of White Matter Repair in Subcortical White Matter IschemiaR37NS102185 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS · 2018 to 2024
$2.8M
Molecular Mechanisms of Axonal Sprouting and Recovery from StrokeR01NS085019 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS085019NINDS NIH HHS R37 NS102185
6 · The paper itself

Abstract

Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the sprouting of new axons, the formation of new synapses and the remapping of sensory-motor functions, and is associated with motor recovery. This is a remarkable process in the adult brain, which is normally constrained in its levels of neuronal plasticity and connectional change. Recent evidence indicates that these changes are driven by molecular systems that underlie learning and memory, such as changes in cellular excitability during memory formation. This Review examines circuit changes after stroke, the shared mechanisms between memory formation and brain repair, the changes in neuronal excitability that underlie stroke recovery, and the molecular and pharmacological interventions that follow from these findings to promote motor recovery in animal models. From these findings, a framework emerges for understanding recovery after stroke, central to which is the concept of neuronal allocation to damaged circuits. The translation of the concepts discussed here to recovery in humans is underway in clinical trials for stroke recovery drugs.

Indexed as

Stroke RehabilitationAnimalsCerebral CortexHumansNeuronal PlasticityStroke

Identifiers

PMID33184469
PMCPMC10625167
OpenAlexW3103993879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.