ArticleCommunications biology2020
Fungal-bacterial interaction selects for quorum sensing mutants with increased production of natural antifungal compounds.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Chemical Interactions between the Common Soil Bacteria Pseudomonas chlororaphis and Bacillus subtilis.ACS chemical biology · 2026Article
- Draft genome of a deep-seaMicrobiology resource announcements · 2026Article
- Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.Natural product reports · 2026Review
- Navigating complexity: key considerations for studying fungal-bacterial interactions.mSystems · 2026Article
- From Molecules to Metabolomes, Understanding Symbiosis through Small Molecules.Journal of natural products · 2026Review
- Analysis and engineering of quorum sensing-based communications between bacteria and fungi.mBio · 2026Review
- Regulatory rewiring drives intraspecies competition in Bacillus subtilis.PLoS genetics · 2026Article
- Review
- Inducible Volatile Chemical Signalling Drives Antifungal Activity of Trichoderma hamatum GD12 During Confrontation With the Pathogen Sclerotinia sclerotiorum.Environmental microbiology reports · 2025Article
- Dynamic regulation of iturin production via reconstructing the quorum-sensing system ComQXPA in Bacillus subtilis.World journal of microbiology & biotechnology · 2025Article
- Emergence of Rhodotorula mucilaginosa among pet animals: a possible public health risk on the move.BMC microbiology · 2025Article
- Bioluminescent Whole-Cell Bioreporter Bacterial Panel for Sustainable Screening and Discovery of Bioactive Compounds Derived from Mushrooms.Biosensors · 2024Article
- Widespread fungal-bacterial competition for magnesium lowers bacterial susceptibility to polymyxin antibiotics.PLoS biology · 2024Article
- Enhanced surface colonisation and competition during bacterial adaptation to a fungus.Nature communications · 2024Article
- Nicotinic Acid Catabolism Modulates Bacterial Mycophagy in Burkholderia gladioli Strain NGJ1.Microbiology spectrum · 2023Article
- Insights into Antifungal Mechanisms of Bacillus velezensis S141 against Cercospora Leaf Spot in Mungbean (V. radiata).Microbes and environments · 2023Article
- Bacterial-fungal interactions under agricultural settings: from physical to chemical interactions.Stress biology · 2022Review
- Mass spectrometry-based metabolomics in microbiome investigations.Nature reviews. Microbiology · 2022Review
- Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features.Communications biology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Soil microorganisms coexist and interact showing antagonistic or mutualistic behaviors. Here, we show that an environmental strain of Bacillus subtilis undergoes heritable phenotypic variation upon interaction with the soil fungal pathogen Setophoma terrestris (ST). Metabolomics analysis revealed differential profiles in B. subtilis before (pre-ST) and after (post-ST) interacting with the fungus, which paradoxically involved the absence of lipopeptides surfactin and plipastatin and yet acquisition of antifungal activity in post-ST variants. The profile of volatile compounds showed that 2-heptanone and 2-octanone were the most discriminating metabolites present at higher concentrations in post-ST during the interaction process. Both ketones showed strong antifungal activity, which was lost with the addition of exogenous surfactin. Whole-genome analyses indicate that mutations in ComQPXA quorum-sensing system, constituted the genetic bases of post-ST conversion, which rewired B. subtilis metabolism towards the depletion of surfactins and the production of antifungal compounds during its antagonistic interaction with S. terrestris.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.