Evidence map›Paper›PMID 33184391›Full record

ArticleScientific reports2020

Prediction of vascular aging based on smartphone acquired PPG signals.

Lorenzo Dall'Olio, Nico Curti, Daniel Remondini, Yosef Safi Harb, Folkert W Asselbergs, Gastone Castellani, Hae-Won Uh

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Lorenzo Dall'OlioDepartment of Physics and Astronomy, University of Bologna, 40126, Bologna, BO, Italy.
Nico CurtiDepartment of Specialised, Diagnostic and Experimental Medicine, University of Bologna, 40126, Bologna, BO, Italy.
Daniel RemondiniDepartment of Physics and Astronomy, University of Bologna, 40126, Bologna, BO, Italy.
Yosef Safi HarbHappitech, 1015 BT, Amsterdam, The Netherlands.
Folkert W AsselbergsDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Gastone CastellaniDepartment of Specialised, Diagnostic and Experimental Medicine, University of Bologna, 40126, Bologna, BO, Italy.
Hae-Won UhDepartment of Biostatistics and Research Support, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands. h.w.uh@umcutrecht.nl.
University of Bologna · ITUniversity College London · GBUniversity Medical Center Utrecht · NL

Funding

Marie Curie 721815
6 · The paper itself

Abstract

Photoplethysmography (PPG) measured by smartphone has the potential for a large scale, non-invasive, and easy-to-use screening tool. Vascular aging is linked to increased arterial stiffness, which can be measured by PPG. We investigate the feasibility of using PPG to predict healthy vascular aging (HVA) based on two approaches: machine learning (ML) and deep learning (DL). We performed data preprocessing, including detrending, demodulating, and denoising on the raw PPG signals. For ML, ridge penalized regression has been applied to 38 features extracted from PPG, whereas for DL several convolutional neural networks (CNNs) have been applied to the whole PPG signals as input. The analysis has been conducted using the crowd-sourced Heart for Heart data. The prediction performance of ML using two features (AUC of 94.7%) - the a wave of the second derivative PPG and tpr, including four covariates, sex, height, weight, and smoking - was similar to that of the best performing CNN, 12-layer ResNet (AUC of 95.3%). Without having the heavy computational cost of DL, ML might be advantageous in finding potential biomarkers for HVA prediction. The whole workflow of the procedure is clearly described, and open software has been made available to facilitate replication of the results.

Indexed as

Deep LearningNeural Networks, ComputerAdolescentAdultAgedAgingFemaleHeart RateHumansMaleMiddle AgedPhotoplethysmographySignal Processing, Computer-AssistedSmartphoneVascular DiseasesYoung Adult

Identifiers

PMID33184391
PMCPMC7661535
OpenAlexW3102010087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.