ArticleScientific reports2020
High definition transcranial direct current stimulation modulates abnormal neurophysiological activity in post-stroke aphasia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Biomarker use in predicting transcranial direct-current stimulation (tDCS) response: a systematic scoping review.Frontiers in psychiatry · 2026Pooled it
- Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial.Neural plasticity · 2024Trial
- MRI-guided personalized tDCS planning for target engagement of the swallowing motor cortex after stroke: a finite-element modeling study.Frontiers in neurology · 2026Article
- On the Effects of Non-Invasive Brain Stimulation Techniques on Developmental Dyslexia: A Systematic Review of Randomized Controlled Trials.Iranian journal of psychiatry · 2025Review
- From data to decisions: AI and functional connectivity for diagnosis, prognosis, and recovery prediction in stroke.GeroScience · 2025Article
- EEG reveals brain network alterations in chronic aphasia during natural speech listening.Scientific reports · 2025Article
- A review on the reporting and assessment of adverse effects associated with high-definition transcranial direct current stimulation.Frontiers in human neuroscience · 2025Review
- Behavioral and neural effects of temporoparietal high-definition transcranial direct current stimulation in logopenic variant primary progressive aphasia: a preliminary study.Frontiers in psychology · 2025Article
- Treatment of aphasia in linguistically diverse populations: current and future directions.Frontiers in psychology · 2025Review
- Secondary thalamic dysfunction underlies abnormal large-scale neural dynamics in chronic stroke.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Early Boost of Linguistic Skills? Individualized Non-Invasive Brain Stimulation in Early Postacute Aphasia.Brain sciences · 2024Article
- Brain complexity in stroke recovery after bihemispheric transcranial direct current stimulation in mice.Brain communications · 2024Article
- Entropy in Electroencephalographic Signals Modulates with Force Magnitude During Grasping - A Preliminary Report.Journal of motor behavior · 2024Article
- Pars Opercularis Underlies Efferent Predictions and Successful Auditory Feedback Processing in Speech: Evidence From Left-Hemisphere Stroke.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Test-retest reliability of fNIRS in resting-state cortical activity and brain network assessment in stroke patients.Biomedical optics express · 2023Article
- Article
- Spectral slowing in chronic stroke reflects abnormalities in both periodic and aperiodic neural dynamics.NeuroImage. Clinical · 2023Article
- Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023Review
- Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke.Current neurology and neuroscience reports · 2022Review
- Effects of Acupuncture-Related Therapies in the Rehabilitation of Patients with Post-Stroke Aphasia-A Network Meta-Analysis of Randomized Controlled Trials.Brain sciences · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings indicate that measures derived from resting-state magnetoencephalography (rsMEG) are sensitive to cortical dysfunction in post-stroke aphasia. Spectral power and multiscale entropy (MSE) measures show that left-hemispheric areas surrounding the stroke lesion (perilesional) exhibit pathological oscillatory slowing and alterations in signal complexity. In the current study, we tested whether individually-targeted high-definition transcranial direct current stimulation (HD-tDCS) can reduce MEG abnormalities and transiently improve language performance. In eleven chronic aphasia survivors, we devised a method to localize perilesional areas exhibiting peak MSE abnormalities, and subsequently targeted these areas with excitatory/anodal-tDCS, or targeted the contralateral homolog areas with inhibitory/cathodal-tDCS, based on prominent theories of stroke recovery. Pathological MEG slowing in these patients was correlated with aphasia severity. Sentence/phrase repetition accuracy was assessed before and after tDCS. A delayed word reading task was administered inside MEG to assess tDCS-induced neurophysiological changes in relative power and MSE computed on the pre-stimulus and delay task time windows. Results indicated increases in repetition accuracy, decreases in contralateral theta (4-7 Hz) and coarse-scale MSE (slow activity), and increases in perilesional low-gamma (25-50 Hz) and fine-scale MSE (fast activity) after anodal-tDCS, indicating reversal of pathological abnormalities. RsMEG may be a sensitive measure for guiding therapeutic tDCS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.