Evidence map›Paper›PMID 33184348›Full record

ArticleScientific reports2020

Disruption of Streptococcus mutans and Candida albicans synergy by a commensal streptococcus.

Joshua T Huffines, Jessica A Scoffield

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. TheApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. Artemisinins inhibited the synergistic cariogenic effect betweenFrontiers in cellular and infection microbiology · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.Dental materials : official publication of the Academy of Dental Materials · 2024
    Article
  11. Article
  12. Unveiling the complexity of early childhood caries:Journal of oral microbiology · 2024
    Review
  13. Article
  14. Article
  15. Catalase produced bymSphere · 2023
    Article
  16. Article
  17. Inhibitory effects of Stevioside onFrontiers in microbiology · 2023
    Article
  18. Current and prospective therapeutic strategies: tacklingFrontiers in cellular and infection microbiology · 2023
    Review
  19. Review
  20. Pharmaceutics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua T HuffinesDepartment of Microbiology, School of Medicine, University of Alabama At Birmingham, 845 19th St. South, Room 744A, Birmingham, AL, 35205, USA.
Jessica A ScoffieldDepartment of Microbiology, School of Medicine, University of Alabama At Birmingham, 845 19th St. South, Room 744A, Birmingham, AL, 35205, USA. jscoff@uab.edu.
University of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
Inhibition of Streptococcus mutans by oral commensal streptococci and nitrie-mediated activityR00DE025913 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCOFFIELD, JESSICA A · 2018 to 2020
$749k
NIDCR NIH HHS R00 DE025913NIDDK NIH HHS P30 DK072482NIGMS NIH HHS T32 GM008111
6 · The paper itself

Abstract

Polymicrobial interactions in dental plaque play a significant role in dysbiosis and homeostasis in the oral cavity. In early childhood caries, Streptococcus mutans and Candida albicans are often co-isolated from carious lesions and associated with increased disease severity. Studies have demonstrated that metabolic and glucan-dependent synergism between C. albicans and S. mutans contribute to enhanced pathogenesis. However, it is unclear how oral commensals influence pathogen synergy. Streptococcus parasanguinis, a hydrogen peroxide (H

Indexed as

BiofilmsCandida albicansGlucansGlucosyltransferasesHydrogen PeroxideMetabolomicsStreptococcusStreptococcus mutansSucroseSymbiosisGlucansGlucosyltransferasesHydrogen PeroxideSucrose

Identifiers

PMID33184348
PMCPMC7661713
OpenAlexW3101930265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.