Evidence map›Paper›PMID 33184324›Full record

ArticleScientific reports2020

Engineering bioactive surfaces on nanoparticles and their biological interactions.

Meghana Matur, Harishkumar Madhyastha, T S Shruthi, Radha Madhyastha, S P Srinivas, P N Navya, Hemant Kumar Daima

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 47 citations in OpenAlex.

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  12. Synthesis, Characterization, andFrontiers in bioengineering and biotechnology · 2022
    Article
  13. Article
  14. Nanozymes to fight the COVID-19 and future pandemics.Environmental chemistry letters · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Meghana MaturNano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India.
Harishkumar MadhyasthaDepartment of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, 8891692, Japan.
T S ShruthiNano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India.
Radha MadhyasthaDepartment of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, 8891692, Japan.
S P SrinivasSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA.
P N NavyaNano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India. navyapn@sit.ac.in.ORCID 0000-0001-9345-8253
Hemant Kumar DaimaNano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India. hkdaima@jpr.amity.edu.ORCID 0000-0002-9109-430X
Siddaganga Institute of Technology · INUniversity of Miyazaki · JPDepartment of Biotechnology · INIndiana University Bloomington · USTumkur University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gallate, and curcumin as reducing and stabilizing agents. The nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxicity. We have thus developed avenues for engineering the surface of nanoparticles for biological applications.

Indexed as

DNA DamageAnimalsCells, CulturedCell SurvivalFibroblastsFree Radical ScavengersGoldMacrophagesMetal NanoparticlesMicePeroxidaseSilverSurface PropertiesFree Radical ScavengersGoldPeroxidaseSilver

Identifiers

PMID33184324
PMCPMC7665184
OpenAlexW3102741827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.