ArticleScientific reports2020
Selection of sponge-associated bacteria with high potential for the production of antibacterial compounds.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- LC-HRMS-Based Metabolomic Profiling and Antioxidant Activity ofAntioxidants (Basel, Switzerland) · 2026Article
- Joining Forces Against Antibiotic Resistance in Aquaculture: The Synergism Between Natural Compounds and Antibiotics.Antibiotics (Basel, Switzerland) · 2026Review
- Marine Bacteria as a Source of Antibiotics AgainstMarine drugs · 2026Review
- Effects of Fermentation Period on Metabolite Production and Bioactivity in Two Sponge-Associated Bacteria.Scientifica · 2026Article
- The Antimicrobial and Cytotoxic Activity of Green-Synthesized Silver Nanoparticle Extract of Marine Bacteria and Their 16S rRNA Identification and Characterization.Bioinorganic chemistry and applications · 2026Article
- The impact of tropodithietic acid on microbial physiology under varying culture complexities.mSphere · 2025Article
- Antimicrobial Metabolites Isolated from Some Marine Bacteria Associated withMicroorganisms · 2025Article
- Article
- Identification and Antimicrobial Potential of Marine Sponges (International journal of microbiology · 2025Article
- Diversity and Activity of Bacteria Cultured from a Cup-The SpongeMarine drugs · 2024Article
- Antagonistic Activity of Oroxylin A againstToxins · 2023Article
- Article
- Antimicrobial Biosynthetic Potential and Phylogenetic Analysis of Culturable Bacteria Associated with the SpongeMarine drugs · 2022Article
- Impact of growth media and pressure on the diversity and antimicrobial activity of isolates from two species of hexactinellid sponge.Microbiology (Reading, England) · 2021Article
- Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds.Marine drugs · 2021Review
- Article
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Authors and funding
12 authors.
Funding
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Abstract
The potential of sponge-associated bacteria for the biosynthesis of natural products with antibacterial activity was evaluated. In a preliminary screening 108 of 835 axenic isolates showed antibacterial activity. Active isolates were identified by 16S rRNA gene sequencing and selection of the most promising strains was done in a championship like approach, which can be done in every lab and field station without expensive equipment. In a competition assay, strains that inhibited most of the other strains were selected. In a second round, the strongest competitors from each host sponge competed against each other. To rule out that the best competitors selected in that way represent similar strains with the same metabolic profile, BOX PCR experiments were performed, and extracts of these strains were analysed using metabolic fingerprinting. This proved that the strains are different and have various metabolic profiles, even though belonging to the same genus, i.e. Bacillus. Furthermore, it was shown that co-culture experiments triggered the production of compounds with antibiotic activity, i.e. surfactins and macrolactin A. Since many members of the genus Bacillus possess the genetic equipment for the biosynthesis of these compounds, a potential synergism was analysed, showing synergistic effects between C14-surfactin and macrolactin A against methicillin-resistant Staphylococcus aureus (MRSA).
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