Evidence map›Paper›PMID 33184301›Full record

ArticleScientific reports2020

Context aware deep learning for brain tumor segmentation, subtype classification, and survival prediction using radiology images.

Linmin Pei, Lasitha Vidyaratne, Md Monibor Rahman, Khan M Iftekharuddin

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Glioblastoma survival prediction through MRI and clinical data integration with transfer learning.International journal of computer assisted radiology and surgery · 2026
    Article
  3. Mamba-based brain tumor segmentation of incomplete multi-modal MR images.Quantitative imaging in medicine and surgery · 2026
    Article
  4. Article
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  6. OVERALL SURVIVAL PREDICTION OF BRAIN TUMOR PATIENTS WITH MULTIMODAL MRI USING SWIN UNETR.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Linmin PeiVision Lab, Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23529, USA.
Lasitha VidyaratneVision Lab, Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23529, USA.
Md Monibor RahmanVision Lab, Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23529, USA.
Khan M IftekharuddinVision Lab, Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23529, USA. kiftekha@odu.edu.

Funding

Quantitative imaging and molecular data modeling for brain tumor recurrence and progression analysisR01EB020683 · NIBIB · OLD DOMINION UNIVERSITY · PI Khan M Iftekharuddin · 2016 to 2026
$3.2M
NIBIB NIH HHS R01 EB020683NIH HHS R01EB020683
6 · The paper itself

Abstract

A brain tumor is an uncontrolled growth of cancerous cells in the brain. Accurate segmentation and classification of tumors are critical for subsequent prognosis and treatment planning. This work proposes context aware deep learning for brain tumor segmentation, subtype classification, and overall survival prediction using structural multimodal magnetic resonance images (mMRI). We first propose a 3D context aware deep learning, that considers uncertainty of tumor location in the radiology mMRI image sub-regions, to obtain tumor segmentation. We then apply a regular 3D convolutional neural network (CNN) on the tumor segments to achieve tumor subtype classification. Finally, we perform survival prediction using a hybrid method of deep learning and machine learning. To evaluate the performance, we apply the proposed methods to the Multimodal Brain Tumor Segmentation Challenge 2019 (BraTS 2019) dataset for tumor segmentation and overall survival prediction, and to the dataset of the Computational Precision Medicine Radiology-Pathology (CPM-RadPath) Challenge on Brain Tumor Classification 2019 for tumor classification. We also perform an extensive performance evaluation based on popular evaluation metrics, such as Dice score coefficient, Hausdorff distance at percentile 95 (HD95), classification accuracy, and mean square error. The results suggest that the proposed method offers robust tumor segmentation and survival prediction, respectively. Furthermore, the tumor classification results in this work is ranked at second place in the testing phase of the 2019 CPM-RadPath global challenge.

Indexed as

Deep LearningMachine LearningNeural Networks, ComputerAlgorithmsBrain NeoplasmsFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePrognosisSurvival Rate

Identifiers

PMID33184301
PMCPMC7665039

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.