Evidence map›Paper›PMID 33184218›Full record

ArticleGenes & development2020

FGF signaling regulates development by processes beyond canonical pathways.

Ayan T Ray, Pierre Mazot, J Richard Brewer, Catarina Catela, Colin J Dinsmore, Philippe Soriano

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  7. Article
  8. Article
  9. DiverseGenes & development · 2024
    Article
  10. [Role of Fibroblast Growth Factor 7 in Craniomaxillofacial Development].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  11. DiversebioRxiv : the preprint server for biology · 2024
    Article
  12. Review
  13. Article
  14. Characterizing the role of Pdgfra in calvarial development.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  15. Article
  16. Article
  17. FGF signaling in cranial suture development and related diseases.Frontiers in cell and developmental biology · 2023
    Review
  18. Article
  19. Cleft Palate in Apert Syndrome.Journal of developmental biology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ayan T RayDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Pierre MazotDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
J Richard BrewerDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Catarina CatelaDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Colin J DinsmoreDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.ORCID 0000-0002-6404-1202
Philippe SorianoDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.ORCID 0000-0002-0427-926X
Icahn School of Medicine at Mount Sinai · US

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4M
FGF Signaling Pathways and Craniofacial DevelopmentR01DE022778 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SORIANO, PHILIPPE M · 2012 to 2022
$6.6M
SRF Modularity During Craniofacial DevelopmentF32DE026678 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DINSMORE, COLIN J · 2016 to 2019
$185k
NCI NIH HHS P30 CA196521NIDCR NIH HHS F32 DE026678NIDCR NIH HHS R01 DE022778
6 · The paper itself

Abstract

FGFs are key developmental regulators that engage a signal transduction cascade through receptor tyrosine kinases, prominently engaging ERK1/2 but also other pathways. However, it remains unknown whether all FGF activities depend on this canonical signal transduction cascade. To address this question, we generated allelic series of knock-in

Indexed as

AnimalsCell AdhesionCell DeathCells, CulturedFibroblast Growth FactorsGene Expression Regulation, DevelopmentalMiceMutationNeural CrestProtein KinasesReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorSignal TransductionFgfr1 protein, mouseFgfr2 protein, mouseFibroblast Growth FactorsProtein KinasesReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth Factorcell adhesioncraniofacial developmentERK1/2FGFneural crest

Identifiers

PMID33184218
PMCPMC7706708
OpenAlexW3104957113

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.