Evidence map›Paper›PMID 33184178›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Leukotriene B

Ana Carolina Guerta Salina, Stephanie L Brandt, Nathan Klopfenstein, Amondrea Blackman, Júlia Miranda Ribeiro Bazzano, Anderson Sá-Nunes, Nicole Byers-Glosson, Claudia Brodskyn, Natalia Machado Tavares, Icaro Bonyek Santos Da Silva and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Article
  8. Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024
    Review
  9. Article
  10. Distinct Mechanisms of Type 3 Secretion System Recognition Control LTBbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Review
  13. Leukotrienes in Innate Immunity: Still Underappreciated after All These Years?Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  14. Article
  15. An inhibitor of leukotriene-AProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Role of neutrophils in type 2 diabetes and associated atherosclerosis.The international journal of biochemistry & cell biology · 2021
    Review
  17. LTBDiabetes · 2021
    Article
  18. Review
  19. Leukotriene BBiomedicines · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ana Carolina Guerta SalinaDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0003-3220-0413
Stephanie L BrandtDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.
Nathan KlopfensteinDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.
Amondrea BlackmanDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0003-0785-938X
Júlia Miranda Ribeiro BazzanoDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0001-9847-4623
Anderson Sá-NunesDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0002-1859-4973
Nicole Byers-GlossonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-3082.
Claudia BrodskynOswaldo Cruz Foundation, Gonçalo Moniz Institute, FIOCRUZ, Salvador 40296-710, Brazil.
Natalia Machado TavaresOswaldo Cruz Foundation, Gonçalo Moniz Institute, FIOCRUZ, Salvador 40296-710, Brazil.ORCID 0000-0002-4026-679X
Icaro Bonyek Santos Da SilvaOswaldo Cruz Foundation, Gonçalo Moniz Institute, FIOCRUZ, Salvador 40296-710, Brazil.ORCID 0000-0002-0346-9360
Alexandra I MedeirosDepartment of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
C Henrique SerezaniDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232; h.serezan@vanderbilt.edu.ORCID 0000-0002-5363-415X
Vanderbilt University Medical Center · USFundação Oswaldo Cruz · BRIndiana University School of MedicineUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Immunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0M
Phosphatase and tensin homolog PTEN actions in polymicrobial sepsisR01HL124159 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2014 to 2022
$4.2M
Prostaglandin E2 Actions and Enhanced Susceptibility to Skin Infection in Diabetic MiceR01DK122147 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2020 to 2022
$1.7M
Immunological Mechanisms of Disease Training ProgramT32AI138932 · NIAID · VANDERBILT UNIVERSITY · PI MAJOR, AMY S, RATHMELL, JEFFREY C. · 2019 to 2023
$1.4M
Mechanisms underlying poor skin host defense in diabetic conditionsR21AI149207 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2020 to 2021
$467k
NHLBI NIH HHS R01 HL124159NIAID NIH HHS R21 AI149207NIAID NIH HHS T32 AI060519NIAID NIH HHS T32 AI138932NIDDK NIH HHS R01 DK122147
6 · The paper itself

Abstract

The initial production of inflammatory mediators dictates host defense as well as tissue injury. Inflammasome activation is a constituent of the inflammatory response by recognizing pathogen and host-derived products and eliciting the production of IL-1β and IL-18 in addition to inducing a type of inflammatory cell death termed "pyroptosis." Leukotriene B

Indexed as

Host-Pathogen InteractionsSkin Physiological PhenomenaAnimalsBiopsyCytokinesImmunity, InnateInflammasomesInflammation MediatorsLeukotriene B4MacrophagesMethicillin-Resistant Staphylococcus aureusMiceSkinCytokinesInflammasomesInflammation MediatorsLeukotriene B4inflammasomeinnate immunityleukotrieneskin

Identifiers

PMID33184178
PMCPMC7720147
OpenAlexW3098806366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.