Evidence map›Paper›PMID 33184172›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen

Christopher Lim, Jason M Berk, Alyssa Blaise, Josie Bircher, Anthony J Koleske, Mark Hochstrasser, Yong Xiong

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Transformation and allelic exchange inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christopher LimDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520.ORCID 0000-0002-8550-9265
Jason M BerkDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520.
Alyssa BlaiseDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520.
Josie BircherDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520.
Anthony J KoleskeDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520.
Mark HochstrasserDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520 mark.hochstrasser@yale.edu yong.xiong@yale.edu.
Yong XiongDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520 mark.hochstrasser@yale.edu yong.xiong@yale.edu.ORCID 0000-0001-9625-9313
Yale University · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Mechanisms of Cell Regulation and Manipulation by the Ubiquitin SystemR35GM136325 · NIGMS · YALE UNIVERSITY · PI Mark W Hochstrasser · 2020 to 2026
$6.5M
DEGRADTION OF SHORT-LIVED REGULATORY PROTEINS IN YEASTR01GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 1992 to 2020
$3.6M
Impact of excitatory synapse maturation on synaptic plasticity and stabilityR01NS105640 · NINDS · YALE UNIVERSITY · PI HIGLEY, MICHAEL JAMES, KOLESKE, ANTHONY J · 2018 to 2022
$2.5M
Control of Dendritic Spine Stability via Regulation of a Stable Actin PoolR01MH115939 · NIMH · YALE UNIVERSITY · PI KOLESKE, ANTHONY J · 2018 to 2022
$2.2M
Recognition of Viral DNA by APOBEC3 Proteins and their Antagonization by HIV VifR01AI116313 · NIAID · YALE UNIVERSITY · PI XIONG, YONG · 2015 to 2019
$2.1M
Direct binding and control of microtubule elongation by Abl2R21NS112121 · NINDS · YALE UNIVERSITY · PI KOLESKE, ANTHONY J · 2020 to 2020
$459k
Regulation of the actin cytoskeleton by Abl2 and its role in dendritic spine stabilityF31NS113511 · NINDS · YALE UNIVERSITY · PI BIRCHER, JOSIE · 2019 to 2021
$94k
NIAID NIH HHS R01 AI116313NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM046904NIGMS NIH HHS R35 GM136325NIMH NIH HHS R01 MH115939NINDS NIH HHS F31 NS113511NINDS NIH HHS R01 NS105640NINDS NIH HHS R21 NS112121
6 · The paper itself

Abstract

Rho family GTPases regulate an array of cellular processes and are often modulated by pathogens to promote infection. Here, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the OtDUB protein encoded by the pathogenic bacterium

Indexed as

Models, MolecularOrientia tsutsugamushiBacterial ProteinsBinding SitesCrystallography, X-RayGuanine Nucleotide Exchange FactorsMultiprotein ComplexesProtein BindingProtein ConformationProtein Interaction Domains and Motifsrac1 GTP-Binding Proteinrho GTP-Binding ProteinsScrub TyphusBacterial ProteinsGuanine Nucleotide Exchange FactorsMultiprotein Complexesrac1 GTP-Binding Proteinrho GTP-Binding Proteinsguanine nucleotide exchange factorOrientia tsutsugamushiRac1scrub typhusX-ray crystallography

Identifiers

PMID33184172
PMCPMC7720168
OpenAlexW3099678463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.