Evidence map›Paper›PMID 33184115›Full record

ArticleThe European respiratory journal2021

Assessment of chronic bronchitis and risk factors in young adults: results from BAMSE.

Gang Wang, Jenny Hallberg, Petra Um Bergström, Christer Janson, Göran Pershagen, Olena Gruzieva, Marianne van Hage, Antonios Georgelis, Anna Bergström, Inger Kull and 2 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05533931 (Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05533931 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2022Enrolled26ConditionsChronic BronchitisArmsResistive Breathing Training group, inspiratory hold technique
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  6. Heterogeneity of reduced FEVRespirology (Carlton, Vic.) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Gang WangDept of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China.
Jenny HallbergDept of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Petra Um BergströmDept of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-2715-2683
Christer JansonDept of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-5093-6980
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Olena GruzievaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Marianne van HageDivision of Immunology and Allergy, Dept of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Antonios GeorgelisInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Inger KullInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anders LindénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden erik.melen@ki.se.ORCID https://orcid.org/0000-0002-8248-0663
Karolinska Institutet · SEKarolinska University Hospital · SESichuan University · CNUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence and early-life risk factors for chronic bronchitis in young adults.

methodsQuestionnaire data and clinical measures from the 24-year follow-up of the Swedish BAMSE (Child (Barn), Allergy, Milieu, Stockholm, Epidemiological) cohort were used. We assessed chronic bronchitis (CB) as the combination of cough and mucus production in the morning during winter. Environmental and clinical data from birth and onwards were used for analyses of risk factors.

resultsAt the 24-year follow-up, 75% (n=3064) participants completed the questionnaire and 2030 performed spirometry. The overall prevalence of CB was 5.5% (n=158) with similar estimates in males and females. 49% of CB cases experienced more than three self-reported respiratory infections in the past year compared to 18% in non-CB subjects (p<0.001), and 37% of cases were current smokers (

conclusionChronic bronchitis in young adults is associated with recurrent respiratory infections. Besides smoking, our results support the role of early-life exposures, such as air pollution and exclusive breastfeeding, for respiratory health later in life.

Indexed as

BronchitisBronchitis, ChronicAgedChildChild, PreschoolFemaleForced Expiratory VolumeHumansInfantMaleRisk FactorsSmokingSpirometryYoung Adult

Identifiers

PMID33184115
PMCPMC7930470
OpenAlexW3102348686

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.