Evidence map›Paper›PMID 33184114›Full record

ArticleBritish journal of sports medicine2021

Aetiology and incidence of sudden cardiac arrest and death in young competitive athletes in the USA: a 4-year prospective study.

Danielle F Peterson, Kristen Kucera, Leah Cox Thomas, Joseph Maleszewski, David Siebert, Martha Lopez-Anderson, Monica Zigman, Jared Schattenkerk, Kimberly G Harmon, Jonathan A Drezner

Open access · bronzeAbstract read
In one paragraph

Article in British journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 5 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 5 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  6. Article
  7. Article
  8. Precision Cardiogenomics in Athletes.International journal of molecular sciences · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Characteristics of sudden cardiac arrest during endurance racing: a decade of the Paris registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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  20. Towards smarter screening: refining ECG criteria for the youngest athletes.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Danielle F PetersonOrthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon, USA.
Kristen KuceraDepartment of Exercise & Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Leah Cox ThomasDuke Cancer Institute, Duke Medicine, Durham, North Carolina, USA.
Joseph MaleszewskiLaboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
David SiebertFamily Medicine, University of Washington, Seattle, Washington, USA.
Martha Lopez-AndersonParent Heart Watch, Orlando, Florida, USA.
Monica ZigmanFamily Medicine, University of Washington, Seattle, Washington, USA.
Jared SchattenkerkUniversity of Rochester School of Medicine & Dentistry, Rochester, New York, USA.
Kimberly G HarmonFamily Medicine, University of Washington, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-3670-6609
Jonathan A DreznerCenter for Sports Cardiology, University of Washington, Seattle, Washington, USA jdrezner@uw.edu.ORCID http://orcid.org/0000-0003-3519-9120
University of Washington · USDuke Medical Center · USMayo Clinic · USOregon Health & Science University · USUniversity of North Carolina at Chapel Hill · USUniversity of Rochester · USWorld Water Watch · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the aetiology and incidence of sudden cardiac arrest and death (SCA/D) in US competitive athletes.

methodsProspective surveillance was conducted from 1 July 2014 to 30 June 2018 through the National Center for Catastrophic Sports Injury Research in collaboration with national sports organisations. Autopsy reports, death certificates, and medical records were reviewed by an expert panel to determine aetiology. Athlete participation statistics from the National Federation of State High School Associations and the National Collegiate Athletic Association (NCAA) were used to calculate incidence rates per athlete-years (AY). Comparisons of incidence rates were calculated using incidence rate ratios (IRR) with 95% CIs.

results331 cases of confirmed SCA/D (158 survivors; 173 fatalities) were identified; 15.4% in middle school, 61.6% in high school and 16.6% in college and professional athletes. Average age was 16.7 (11-29) years, and the majority were in male (83.7%), basketball (28.7%) or American football (25.4%) athletes. Common causes included hypertrophic cardiomyopathy (20.6%), idiopathic left ventricular hypertrophy (13.4%), coronary artery anomalies (12.0%) and autopsy-negative sudden unexplained death (9.6%). Coronary anomalies were more common in middle school athletes (28%), while cardiomyopathies (hypertrophic, arrhythmogenic, dilated, non-compaction or restricted) accounted for 47% of cases in college and professional athletes. Incidence was higher in male versus female athletes at the high school (1:43 932 AY (95% CI 1:38 101 to 1:50 907) vs 1:203 786 AY (95% CI 1:145 251 to 1:293 794); IRR 4.6 (95% CI 3.1 to 7.2)) and NCAA (1:34 906 AY (95% CI 1:25 385 to 1:49 173) vs 1:123 278 AY (95% CI 1:66 078 to 1:249 853); IRR 3.5 (95% CI 1.5 to 9.5)) levels. African American male NCAA Division I basketball players had the highest annual incidence rate of SCA/D (1:2087 AY (95% CI 1:1073 to 1:4 450)).

conclusionsCardiomyopathies account for nearly half of SCA/D cases in college and professional athletes, while coronary artery anomalies play a more prominent role than expected in middle school athletes. Over half of SCA cases in athletes result in sudden death, calling for improved prevention strategies.

Indexed as

SportsAdolescentAdultAthletesCardiomyopathiesCardiomyopathy, HypertrophicChildCoronary Artery DiseaseDeath, Sudden, CardiacFemaleHumansHypertrophy, Left VentricularIncidenceMaleProspective StudiesUnited Statescardiologycardiovasculardeathprevention

Identifiers

PMID33184114
PMCPMC8551972
OpenAlexW3104400207

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.