ArticleCancer research2021
Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of
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In one paragraph
Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 48 citations in OpenAlex.
- Hormone therapy enhances anti-PD1 efficacy in premenopausal estrogen receptor-positive and HER2-negative advanced breast cancer.Cell reports. Medicine · 2025Trial
- ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner.Communications biology · 2026Article
- Article
- Androgen receptor localisation and protein interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer.NPJ breast cancer · 2026Article
- Activating mutations in ESR1 contribute to an immunosuppressive breast tumor microenvironment by dampening cytokine secretion.JCI insight · 2026Article
- Comprehensive metabolic profiling uncovers early variation and biomarkers of esophageal squamous cell carcinoma.Science China. Life sciences · 2026Article
- Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.Endocrinology · 2025Article
- Interaction between Estrogen Receptors and p53: A Broader Role for Tamoxifen?Endocrinology · 2025Review
- Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2025Article
- Construction of a prognostic survival model with tumor immune-related genes for breast cancer.Translational cancer research · 2024Article
- Clinical and immune responses to neoadjuvant fulvestrant with or without enzalutamide in ER+/Her2- breast cancer.NPJ breast cancer · 2024Article
- Liver tropism of ER mutant breast cancer is characterized by unique molecular changes and immune infiltration.Breast cancer research and treatment · 2024Article
- Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies.Endocrinology · 2024Review
- Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling.Scientific reports · 2024Article
- Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor-positive Breast Cancer.Cancer research communications · 2024Article
- Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy.International journal of molecular sciences · 2023Review
- Real-World Use of Highly Sensitive Liquid Biopsy Monitoring in Metastatic Breast Cancer Patients Treated with Endocrine Agents after Exposure to Aromatase Inhibitors.International journal of molecular sciences · 2023Article
- Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs.NAR cancer · 2023Article
- Phase II trial of fulvestrant plus enzalutamide in ER+/HER2- advanced breast cancer.NPJ breast cancer · 2023Article
- Autoimmunity and Carcinogenesis: Their Relationship under the Umbrella of Autophagy.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Michelle M WilliamsDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-7063-9147
Nicole S SpoelstraDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Spencer ArnesenDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.ORCID https://orcid.org/0000-0002-4235-6684
Kathleen I O'NeillDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Jessica L ChristensonDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-6311-8191
Jordan ReeseDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Kathleen C TorkkoDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Andrew GoodspeedDepartment of Pharmacology and University of Colorado Comprehensive Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Emmanuel RosasDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Toru HanamuraDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Sharon B SamsDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Zheqi LiWomen's Cancer Research Center, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center (HCC), Magee-Womens Research Institute, Pittsburgh, Pennsylvania.
Steffi OesterreichWomen's Cancer Research Center, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center (HCC), Magee-Womens Research Institute, Pittsburgh, Pennsylvania.ORCID https://orcid.org/0000-0002-2537-6923
Rebecca B RigginsLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Britta M JacobsenDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0001-8234-1690
Anthony EliasSchool of Medicine, Division of Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-6509-9211
Jason GertzDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Jennifer K RicherDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. jennifer.richer@cuanschutz.edu.ORCID https://orcid.org/0000-0002-9960-0991
University of Colorado Anschutz Medical Campus · USHuntsman Cancer Institute · USUniversity of Pittsburgh · USGeorgetown University · USUniversity of Colorado Cancer Center · US
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MTraining Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5MMechanism-based strategies to target ER-mutant endocrine resistant breast cancerR01CA221303 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OESTERREICH, STEFFI · 2018 to 2022
$2.0MAndrogen Receptor and Intersecting Pathways Critical to Breast Cancer SubtypesR01CA187733 · NCI · UNIVERSITY OF COLORADO DENVER · PI RICHER-MOUCHANTAT, JENNIFER · 2015 to 2019
$1.9MImpact of heme catabolism on triple negative breast cancer metastasis via immune-suppressionF32CA239436 · NCI · UNIVERSITY OF COLORADO DENVER · PI WILLIAMS, MICHELLE M · 2020 to 2021
$142kNCI NIH HHS F32 CA239436NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA187733NCI NIH HHS R01 CA221303NCI NIH HHS T32 CA190216
Abstract
Mutations in
Indexed as
Breast NeoplasmsEstrogen Receptor alphaFulvestrantGene ExpressionHumansMutationEstrogen Receptor alphaFulvestrant
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.