Evidence map›Paper›PMID 33183355›Full record

ArticleAIDS research and therapy2020

Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.

Emmanuel Bahemana, Allahna Esber, Nicole Dear, Kavitha Ganesan, Ajay Parikh, Domonique Reed, Lucas Maganga, Samoel Khamadi, Mucho Mizinduko, Anange Lwilla and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 3 countries.

Emmanuel BahemanaHJF Medical Research International, Inc., Mbeya, Tanzania. ebahemana@wrp-t.org.
Allahna EsberU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. aesber@hivresearch.org.ORCID 0000-0001-5337-0126
Nicole DearU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Kavitha GanesanU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ajay ParikhU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Domonique ReedU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lucas MagangaNational Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania.
Samoel KhamadiHJF Medical Research International, Inc., Mbeya, Tanzania.
Mucho MizindukoMuhimbili University of Health and Allied Science-Dar-Es-Salaam, Dar-Es-Salaam, Tanzania.
Anange LwillaHJF Medical Research International, Inc., Mbeya, Tanzania.
Dorothy MkondooHJF Medical Research International, Inc., Mbeya, Tanzania.
Gwamaka MwaisangaHJF Medical Research International, Inc., Mbeya, Tanzania.
Nancy SomiHJF Medical Research International, Inc., Mbeya, Tanzania.
John OwouthU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jonah MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Francis KiweewaMakerere University Walter Reed Project, Kampala, Uganda.
Michael IroezinduU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Julie A AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Trevor A CrowellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Victor G ValcourMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Christina S PolyakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
AFRICOS Study Group
Henry M. Jackson Foundation · USWalter Reed Army Institute of Research · USMakerere University Walter Reed Project · UGMuhimbili University of Health and Allied Sciences · TZNational Institute for Medical Research · TZUniversity of California, San Francisco · USWWF Tanzania · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWith increased use of antiretroviral therapy (ART), HIV mortality rates are declining and people living with HIV (PLWH) are surviving longer. We characterized CD4 recovery and viral suppression among adults aged < 50 and ≥ 50 years living with HIV who initiated ART in the African Cohort Study (AFRICOS).

methodsBeginning in January 2013, PLWH at twelve clinics in Kenya, Uganda, Tanzania and Nigeria underwent medical history review, CD4 and viral load testing as part of the ongoing African Cohort Study (AFRICOS). ART-naïve PLWH who initiated ART within 30 days of enrollment and had at least one year of follow-up were included in these analyses. To compare ART response in participants < 50 years and ≥ 50 years old, changes in CD4 count and viral load suppression after ART initiation were examined at different time points using linear and binomial regression with generalized estimating equations. Variables for time since ART initiation and the interaction between age group and time on ART were included in the model to evaluate longitudinal changes in CD4 recovery and viral suppression by age.

resultsBetween January 2013 and September 2019, 2918 PLHV were enrolled in the cohort. Of these, 443 were ART naïve and initiated on ART within 30 days of enrollment, with 90% (n = 399) aged < 50 years old at ART initiation. At ART initiation, participants aged 50 and older had a higher median CD4 count compared to participants younger than 50 years of age although it did not reach statistical significance (306 cells/mm

conclusionThis study found no difference in long-term CD4 recovery or viral suppression by age at ART initiation. We found that particularly among younger adults participants had lower median CD4 counts at ART initiation, suggesting the importance of identifying and putting this population on treatment earlier in the disease course.

Indexed as

Anti-HIV AgentsHIV InfectionsAdultAgedCD4 Lymphocyte CountCohort StudiesHumansKenyaMiddle AgedViral LoadAnti-HIV AgentsElders on antiretroviral drugsHIV and agingHIV treatment outcomesSub-saharan Africa

Identifiers

PMID33183355
PMCPMC7664082
OpenAlexW3099771065

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.