Evidence map›Paper›PMID 33183317›Full record

ArticleMolecular brain2020

Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus.

Camille Dumon, Yasmine Belaidouni, Diabe Diabira, Suzanne M Appleyard, Gary A Wayman, Jean-Luc Gaiarsa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Camille DumonAix-Marseille Univ UMR 1249, INSERM (Institut National de La Santé et de La Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de La Méditerranée), Parc Scientifique de Luminy, Marseille, France.
Yasmine BelaidouniAix-Marseille Univ UMR 1249, INSERM (Institut National de La Santé et de La Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de La Méditerranée), Parc Scientifique de Luminy, Marseille, France.
Diabe DiabiraAix-Marseille Univ UMR 1249, INSERM (Institut National de La Santé et de La Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de La Méditerranée), Parc Scientifique de Luminy, Marseille, France.
Suzanne M AppleyardProgram in Neuroscience, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Gary A WaymanProgram in Neuroscience, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Jean-Luc GaiarsaAix-Marseille Univ UMR 1249, INSERM (Institut National de La Santé et de La Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de La Méditerranée), Parc Scientifique de Luminy, Marseille, France. jean-luc.gaiarsa@inserm.fr.ORCID 0000-0001-7354-0559
Inserm · FRWashington State University · US

Funding

Integration of Peripheral and Central Appetite Signals by Brainstem NeuronsR01DK083452 · NIDDK · WASHINGTON STATE UNIVERSITY · PI APPLEYARD, SUZANNE M · 2009 to 2018
$2.9M
Leptin regulation of GABAergic synaptogenesis and excitation-inhibition balance during development: effects of maternal obesityR01HD092369 · NICHD · WASHINGTON STATE UNIVERSITY · PI WAYMAN, GARY ALLEN · 2018 to 2022
$2.0M
NICHD NIH HHS R01 HD092369NIDDK NIH HHS R01 DK083452
6 · The paper itself

Abstract

The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin controls chloride homeostasis in the developing rat hippocampus in vitro. The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. This study confirms and extends the role of leptin in the ontogenesis of functional GABAergic inhibition and helps understanding how abnormal levels of leptin may contribute to neurological disorders.

Indexed as

Down-RegulationHomeostasisAnimalsAnimals, NewbornChloridesHippocampusK Cl- CotransportersLeptinRats, WistarSymportersChloridesK Cl- CotransportersLeptinSymportersChloride homeostasisGABAHippocampusKCC2LeptinMaternal obesityRat

Identifiers

PMID33183317
PMCPMC7661183
OpenAlexW3098070220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.