ArticleBMC endocrine disorders2020
Impact of malnutrition on systemic immune and metabolic profiles in type 2 diabetes.
Article in BMC endocrine disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Global prevalence and moderating factors of malnutrition in colorectal cancer survivors: A meta-analysis.Journal of cancer survivorship : research and practice · 2026Pooled it
- Malnutrition and type 2 diabetes mellitus across diverse global populations: a systematic review of observational evidence.Frontiers in clinical diabetes and healthcare · 2026Pooled it
- Prevalence and influencing factors of malnutrition in diabetic patients: A systematic review and meta-analysis.Journal of diabetes · 2024Pooled it
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Underweight Status Amplifies Respiratory Infection Mortality in Diabetes: Findings From a Nationwide Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Association of the triglyceride glucose-body roundness index with mortality in HFpEF and effect modification by nutritional status: a multicenter prospective cohort study.Lipids in health and disease · 2025Article
- Undernutrition-Associated Diabetes Mellitus: Pathophysiology of a Global Problem.Physiology (Bethesda, Md.) · 2025Review
- Does Food Habits and Malnutrition Affect Health Perception Among Diabetic Patients? A Mediation and Moderation Analysis.Healthcare (Basel, Switzerland) · 2025Article
- Association of Adiponectin and Resistin Gene Polymorphisms with Undernutrition Risk among Type 2 Diabetes Patients in Bosnia and Herzegovina.Iranian journal of public health · 2025Article
- Associations of modified triglyceride-glucose indices and the triglyceride/high-density lipoprotein ratio with all-cause and cause-specific mortality in the general population: an analysis of the UK biobank database.Lipids in health and disease · 2025Article
- Impact of geriatric nutritional risk index and diabetes mellitus on prognosis in ischaemic heart failure with reduced ejection fraction.Scientific reports · 2025Article
- Sex differences in the impact of controlling nutritional status score on diabetic retinopathy: findings of 2003-2018 National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- Sex-specific associations of the controlling nutritional status score with diabetic kidney disease among Chinese individuals: a retrospective cross-sectional study.Frontiers in nutrition · 2025Article
- Geriatric Nutritional Risk Index and mortality in individuals with prediabetes and diabetes: a longitudinal cohort study.Frontiers in nutrition · 2025Article
- Development and validation of a nomogram of all-cause mortality in adult Americans with diabetes.Scientific reports · 2024Article
- Correlation between serum sex hormone-binding globulin levels and nutrition indicators and malnutrition exposure risk in men and postmenopausal women with type 2 diabetes.BMC endocrine disorders · 2024Article
- Association between controlling nutritional status score and chronic kidney disease in diabetic patients: a cross-sectional study based on the National Health and Nutrition Examination Survey.International urology and nephrology · 2024Article
- The prognostic nutrition index is a predictor for long-term outcomes after revascularization in adult moyamoya disease.Acta neurochirurgica · 2023Article
- Article
- Geriatric Nutrition Risk Index as a predictor of cardiovascular and all-cause mortality in older Americans with diabetes.Diabetology & metabolic syndrome · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhile obesity and overweight status are firmly established risk factors for Type 2 diabetes mellitus (T2DM), a substantial proportion of diabetic individuals, especially in Africa and Asia, are often underweight or normal weight. However, very little is known about the immunological and metabolic profiles of these individuals.
methodsThis study aimed to assess the relationship between malnutrition and Type 2 diabetes mellitus (T2DM). We examined a variety of analytes associated with the immunological and metabolic profiles of T2DM individuals with low (< 18.5 kg/m2) or normal (18.5-24.9 kg/m2) body mass index (BMI). To this end, we measured plasma levels of HbA1c, glucose, insulin, glucagon, adipocytokines and Type 1, Type 2, Type 17, pro-inflammatory and regulatory cytokines in T2DM individuals with low BMI (LBMI) or normal BMI (NBMI) with small sample size n = 44 in each group.
resultsLBMI individuals exhibited significantly higher levels of HbA1c, random blood glucose, insulin and glucagon compared to NBMI individuals. Similarly, LBMI individuals exhibited significantly higher levels of adiponectin and adipsin and significantly lower levels of leptin in comparison to NBMI individuals. LBMI individuals also exhibited significantly lower levels of the Type 1, Type 2, Type 17, pro-inflammatory and regulatory cytokines in comparison to NBMI individuals. Finally, while the metabolic parameters exhibited a significant negative correlation with BMI, the immunological parameters exhibited a significant positive correlation with BMI.
conclusionsMalnutrition is associated with a significant modulation of glycemic, hormonal and cytokine parameters in T2DM. Hence, the biochemical and immunological profiles of T2DM is significantly influenced by BMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.