Evidence map›Paper›PMID 33182894›Full record

ArticleOptics express2020

Real-time Jones phase microscopy for studying transparent and birefringent specimens.

Yuheng Jiao, Mikhail E Kandel, Xiaojun Liu, Wenlong Lu, Gabriel Popescu

Abstract readValidation Study
In one paragraph

Article in Optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuheng Jiao
Mikhail E Kandel
Xiaojun Liu
Wenlong Lu
Gabriel Popescu

Funding

Quantitative histopathology for cancer prognosis using quantitative phase imaging on stained tissuesR01CA238191 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANASTASIO, MARK A, ELICEIRI, KEVIN WILLIAM · 2019 to 2023
$3.1M
High accuracy optical growth assay of 3D cellular systemsR01GM129709 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID · 2019 to 2022
$2.1M
NCI NIH HHS R01 CA238191NIGMS NIH HHS R01 GM129709
6 · The paper itself

Abstract

Tissue birefringence is an intrinsic marker of potential value for cancer diagnosis. Traditionally, birefringence properties have been studied by using intensity-based formalisms, through the Mueller matrix algebra. On the other hand, the Jones matrix description allows for a direct assessment of the sample's anisotropic response. However, because Jones algebra is based on complex fields, requiring measurements of both phase and amplitude, it is less commonly used. Here we propose a real-time imaging method for measuring Jones matrices by quantitative phase imaging. We combine a broadband phase imaging system with a polarization-sensitive detector to obtain Jones matrices at each point in a megapixel scale image, with near video rate capture speeds. To validate the utility of our approach, we measured standard targets, partially birefringent samples, dynamic specimens, and thinly sliced histopathological tissue.

Indexed as

BirefringenceAnimalsAnisotropyImage EnhancementImage Processing, Computer-AssistedLigamentsMiceMicroscopy, PolarizationMicrospheresPolystyrenesPolystyrenes

Identifiers

PMID33182894
PMCPMC7679182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.