Evidence map›Paper›PMID 33182766›Full record

ArticleCancers2020

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance.

Richard J Honeywell, Ietje Kathmann, Elisa Giovannetti, Carmelo Tibaldi, Egbert F Smit, Maria N Rovithi, Henk M W Verheul, Godefridus J Peters

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Richard J HoneywellDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Ietje KathmannDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Elisa GiovannettiDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Carmelo TibaldiDivision of Oncology, Department of Oncology, S. Luca Hospital, 55100 Lucca, Italy.
Egbert F SmitDepartment of Thoracic Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Maria N RovithiDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Henk M W VerheulDepartment of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-5981-922X
Godefridus J PetersDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLFondazione Pisa · ITGdańsk Medical University · PLRadboud University Nijmegen · NLThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CaCo2 model systemefflux ratiogut-epithelial transferred blood cell accumulationtyrosine kinase inhibitors

Identifiers

PMID33182766
PMCPMC7696666
OpenAlexW3099491388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.