Evidence map›Paper›PMID 33182753›Full record

ArticleBiomolecules2020

Magnoflorine-Isolation and the Anticancer Potential against NCI-H1299 Lung, MDA-MB-468 Breast, T98G Glioma, and TE671 Rhabdomyosarcoma Cancer Cells.

Estera Okon, Wirginia Kukula-Koch, Marta Halasa, Agata Jarzab, Marzena Baran, Magdalena Dmoszynska-Graniczka, Apostolis Angelis, Eleftherios Kalpoutzakis, Malgorzata Guz, Andrzej Stepulak and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A Theranostic Study ofBioconjugate chemistry · 2026
    Article
  4. Article
  5. Article
  6. Wild-Grown RomanianPlants (Basel, Switzerland) · 2023
    Article
  7. Enhanced Production of Nitrogenated Metabolites with Anticancer Potential inInternational journal of molecular sciences · 2023
    Article
  8. Magnoflorine fromInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Estera OkonDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Wirginia Kukula-KochDepartment of Pharmacognosy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-7076-600X
Marta HalasaDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Agata JarzabDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Marzena BaranDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Magdalena Dmoszynska-GraniczkaDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-6248-0930
Apostolis AngelisLaboratory of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771 Athens, Greece.ORCID 0000-0002-5100-0321
Eleftherios KalpoutzakisLaboratory of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771 Athens, Greece.
Malgorzata GuzDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-6783-8017
Andrzej StepulakDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-1872-394X
Anna WawruszakDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-2388-4577
Medical University of Lublin · PLNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnoflorine (MGN) is a quaternary aporphine alkaloid that exhibits numerous therapeutic properties, including neuropsychopharmacological, anti-anxiety, immunomodulatory, anti-inflammatory, antioxidant, or antifungal activities. The aim of the present study was an investigation of the influence of MGN on viability, proliferation, induction of apoptosis, and cell cycle arrest in NCI-H1299 lung, MDA-MB-468 breast, T98G glioma, and TE671 rhabdomyosarcoma cancer cells. MGN was isolated from the roots of

Indexed as

Antineoplastic AgentsApoptosisAporphinesBerberisBreast NeoplasmsCell Cycle CheckpointsCell Line, TumorCell SurvivalFemaleGliomaHumansPlant ExtractsRhabdomyosarcomaAntineoplastic AgentsAporphinesmagnoflorinePlant Extractsanti-cancer activityBerberidaceaeBerberis creticacounter-current chromatographyCPCHPLC-MSisoquinoline alkaloidsmagnoflorinenatural products

Identifiers

PMID33182753
PMCPMC7696229
OpenAlexW3104267046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.