ArticleDiagnostics (Basel, Switzerland)2020
Cognitive Fatigue Is Associated with Altered Functional Connectivity in Interoceptive and Reward Pathways in Multiple Sclerosis.
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Measuring Fatigue in Multiple Sclerosis: A Rapid Review.The patient · 2025Pooled it
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Functional connectivity modifications in monoaminergic circuits occur in fatigued MS patients treated with fampridine and amantadine.Journal of neurology · 2023Trial
- Towards a domain-general mechanistic model of fatigue: application to Functional Neurological Disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Eight-year longitudinal changes in functional connectivity of the fatigue network in Parkinson's disease: evidence from four timepoints.Brain imaging and behavior · 2026Article
- Functional connectivity dynamics of monoaminergic circuits related to fatigue in multiple sclerosis.Journal of neurology · 2026Article
- The Relationship Between Subjective and Objective Fatigue Assessment Approaches in Multiple Sclerosis: A Meta-Analysis.Neuropsychology review · 2026Review
- The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.Journal of neurology · 2026Article
- Relationship between functional network integrity, cognition and fatigue at long-term follow-up in patients with IDH-mutated gliomas.Frontiers in human neuroscience · 2026Article
- Linking movement-related beta oscillations to cortical excitability, structural damage, and fatigue in multiple sclerosis.Brain communications · 2026Article
- Brain functional connectivity after Stroop task induced cognitive fatigue.Scientific reports · 2025Article
- White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis.Scientific reports · 2025Article
- Graph theory-based analysis of functional connectivity changes in brain networks underlying cognitive fatigue: An EEG study.PloS one · 2025Article
- Self-perceptual blindness to mental fatigue in mining workers.Frontiers in neuroergonomics · 2024Article
- Investigating the influence of an effort-reward interaction on cognitive fatigue in individuals with multiple sclerosis.Journal of neuropsychology · 2023Article
- Structural and functional magnetic resonance imaging correlates of fatigue and dual-task performance in progressive multiple sclerosis.Journal of neurology · 2023Article
- Graph-Based Analysis of Brain Connectivity in Multiple Sclerosis Using Functional MRI: A Systematic Review.Brain sciences · 2023Review
- Insular dysfunction of interoception in major depressive disorder: from the perspective of neuroimaging.Frontiers in psychiatry · 2023Review
- Age-Related Changes in Functional Connectivity during the Sensorimotor Integration Detected by Artificial Neural Network.Sensors (Basel, Switzerland) · 2022Article
- Brain Under Fatigue - Can Perceived Fatigability in Multiple Sclerosis Be Seen on the Level of Functional Brain Network Architecture?Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cognitive fatigue is common and debilitating among persons with multiple sclerosis (pwMS). Neural mechanisms underlying fatigue are not well understood, which results in lack of adequate treatment. The current study examined cognitive fatigue-related functional connectivity among 26 pwMS and 14 demographically matched healthy controls (HCs). Participants underwent functional magnetic resonance imaging (fMRI) scanning while performing a working memory task (n-back), with two conditions: one with higher cognitive load (2-back) to induce fatigue and one with lower cognitive load (0-back) as a control condition. Task-independent residual functional connectivity was assessed, with seeds in brain regions previously implicated in cognitive fatigue (dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex (vmPFC), dorsal anterior cingulate cortex (dACC), insula, and striatum). Cognitive fatigue was measured using the Visual Analogue Scale of Fatigue (VAS-F). Results indicated that as VAS-F scores increased, HCs showed increased residual functional connectivity between the striatum and the vmPFC (crucial in reward processing) during the 2-back condition compared to the 0-back condition. In contrast, pwMS displayed increased residual functional connectivity from interoceptive hubs-the insula and the dACC-to the striatum. In conclusion, pwMS showed a hyperconnectivity within the interoceptive network and disconnection within the reward circuitry when experiencing cognitive fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.