Evidence map›Paper›PMID 33182663›Full record

ReviewMedicina (Kaunas, Lithuania)2020

The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development.

Ayumi Ono, Masafumi Koshiyama, Miwa Nakagawa, Yumiko Watanabe, Eri Ikuta, Keiko Seki, Makiko Oowaki

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07320183 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of a Dietary Supplement Containing EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid in Supporting Male Genital Balance in Subjects Exposed to HPV Risk

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2028Enrolled96ConditionsHPV - Anogenital Human Papilloma Virus Infection, InfertilitiesArmspervistop
NCT07344337 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Effect of a Dietary Supplement Based on EGCG, Vitamin B12, Hyaluronic Acid, and Folic Acid on the Maintenance of Physiological Balance and the Natural Defenses of the Male Genital System in Subjects Exposed to HPV Infection.

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2028Enrolled96ConditionsHPV Infection, InfertilitiesArmsPervistop
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. The dietary inflammatory index (DIIBMC public health · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer.International journal of molecular sciences · 2023
    Review
  17. Review
  18. Review
  19. Fermented Mangosteen (Cancers · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ayumi OnoGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.
Masafumi KoshiyamaDepartment of Women's Health, Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.ORCID 0000-0003-2412-4430
Miwa NakagawaGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.
Yumiko WatanabeDepartment of Women's Health, Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.
Eri IkutaGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.
Keiko SekiGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.
Makiko OowakiGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan.
University of Shiga Prefecture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail.

Indexed as

Papillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAntioxidantsDietFemaleHumansAntioxidantscervical cancercervical dysplasiadietary oxidantHPV

Identifiers

PMID33182663
PMCPMC7698010
OpenAlexW3103331511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.