Evidence map›Paper›PMID 33182400›Full record

ArticleInternational journal of molecular sciences2020

The FKBP4 Gene, Encoding a Regulator of the Androgen Receptor Signaling Pathway, Is a Novel Candidate Gene for Androgen Insensitivity Syndrome.

Erkut Ilaslan, Renata Markosyan, Patrick Sproll, Brian J Stevenson, Malgorzata Sajek, Marcin P Sajek, Hasmik Hayrapetyan, Tamara Sarkisian, Ludmila Livshits, Serge Nef and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Erkut IlaslanInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-1024-7491
Renata MarkosyanEndocrinology Department, "Muratsan" University Hospital, Endocrinology Clinic, Yerevan State Medical University, 0025 Yerevan, Armenia.ORCID 0000-0003-0860-2340
Patrick SprollDivision of Endocrinology, University of Fribourg, 1700 Fribourg, Switzerland.
Brian J StevensonSIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Malgorzata SajekDepartment of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.ORCID 0000-0003-0599-7543
Marcin P SajekInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-4115-4191
Hasmik HayrapetyanDepartment of Medical Genetics, Yerevan State Medical University, 0025 Yerevan, Armenia.ORCID 0000-0003-0162-2680
Tamara SarkisianDepartment of Medical Genetics, Yerevan State Medical University, 0025 Yerevan, Armenia.ORCID 0000-0002-4767-7567
Ludmila LivshitsInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 03143 Kyiv, Ukraine.ORCID 0000-0001-5444-3964
Serge NefDepartment of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, CH-1211 Genève 4, Switzerland.ORCID 0000-0001-5462-0676
Jadwiga JaruzelskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-2355-0729
Kamila Kusz-ZamelczykInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-6567-1193
Institute of Human Genetics · PLCenter of Medical Genetics and Primary Health Care · AMNational Academy of Sciences of Ukraine · UASIB Swiss Institute of Bioinformatics · CHUniversity of Fribourg · CHUniversity of Geneva · CHYerevan State Medical University · AM

Funding

Swiss National Science Foundation SCOPES IZ73Z0_152347/1
6 · The paper itself

Abstract

Androgen insensitivity syndrome (AIS), manifesting incomplete virilization in 46,XY individuals, is caused mostly by androgen receptor (AR) gene mutations. Therefore, a search for

Indexed as

Amino Acid SequenceAmino Acid SubstitutionAndrogen-Insensitivity SyndromeChildExomeHumansMaleMutationReceptors, AndrogenSexual DevelopmentSignal TransductionTacrolimus Binding ProteinsReceptors, Androgentacrolimus binding protein 4Tacrolimus Binding Proteinsandrogen insensitivity syndrome (AIS)androgen receptor signalingdisorder of sexual development (DSD)FKBP4partial androgen insensitivity syndrome (PAIS)

Identifiers

PMID33182400
PMCPMC7664851
OpenAlexW3106225134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.