Evidence map›Paper›PMID 33182370›Full record

ArticleInternational journal of molecular sciences2020

CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.

Yangyang Shen, Yan Zou, Jun Li, Fanghui Chen, Honglin Li, Yafei Cai

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. CDK5RAP3 Regulates Testosterone Production in Mouse Leydig Cells.International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. UFL1 promotes survival and function of virtual memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yangyang ShenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-8177-4766
Yan ZouCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-1719-9197
Jun LiCollege of Life Sciences, Anhui Normal University, Wuhu 241000, China.
Fanghui ChenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Honglin LiDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Yafei CaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Nanjing Agricultural University · CNAnhui Normal University · CNAugusta University · US

Funding

Essential role of the Ufm1 E3 ligase in intestinal homeostasisR01DK113409 · NIDDK · AUGUSTA UNIVERSITY · PI LI, HONGLIN · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK113409
6 · The paper itself

Abstract

CDK5RAP3 was regarded as the most significant regulator of cellular responses against heat stress, which is associated with dysfunctions of the immune system and animal susceptibility to disease. Despite this, little known about how CDK5RAP3 regulates heat stress response. In this study, CDK5RAP3 conditional Knockout (CKO) mice, CDK5RAP3

Indexed as

AnimalsApoptosisCattleCell Cycle ProteinsCell NucleusCells, CulturedCytoplasmDown-RegulationEndoplasmic Reticulum StressEpithelial CellsFemaleHeat-Shock ResponseHeat Shock Transcription FactorsHSP90 Heat-Shock ProteinsMammalsMiceCdk5rap3 protein, mouseCell Cycle ProteinsHeat Shock Transcription FactorsHsf1 protein, mouseHSP90 Heat-Shock ProteinsMolecular ChaperonesTumor Suppressor ProteinsCDK5RAP3heat stress responseHSF1HSP90nucleoplasmic shuttle

Identifiers

PMID33182370
PMCPMC7664939
OpenAlexW3105788470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.