Evidence map›Paper›PMID 33182365›Full record

ArticleInternational journal of molecular sciences2020

Platelet-Reactive Antibodies in Patients after Ischaemic Stroke-An Epiphenomenon or a Natural Protective Mechanism.

Young Eun Park, Rushi Penumarthy, Paul P Sun, Caroline Y Kang, Marie-Christine Morel-Kopp, Jonathan Downing, Taryn N Green, Tracey Immanuel, Christopher M Ward, Deborah Young and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

Young Eun ParkBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0001-9912-5513
Rushi PenumarthyBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.
Paul P SunBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.
Caroline Y KangBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.
Marie-Christine Morel-KoppDepartment of Haematology and Transfusion Medicine, Royal North Shore Hospital, Sydney 2065, Australia.ORCID 0000-0003-4795-1746
Jonathan DowningNew Zealand Blood Service Centre, Auckland 1051, New Zealand.
Taryn N GreenBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.
Tracey ImmanuelBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.
Christopher M WardDepartment of Haematology and Transfusion Medicine, Royal North Shore Hospital, Sydney 2065, Australia.
Deborah YoungDepartment of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0003-1085-2824
Matthew J DuringCentre for Brain Research, University of Auckland, Auckland 1142, New Zealand.
P Alan BarberCentre for Brain Research, University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0003-2469-9023
Maggie L Kalev-ZylinskaBlood and Cancer Biology Laboratory, Department of Molecular Medicine & Pathology, University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0001-8378-8048
University of Auckland · NZThe University of Sydney · AU

Funding

Marsden Fund UOA0903
6 · The paper itself

Abstract

Ischaemic brain damage induces autoimmune responses, including the production of autoantibodies with potential neuroprotective effects. Platelets share unexplained similarities with neurons, and the formation of anti-platelet antibodies has been documented in neurological disorders. The aim of this study was to investigate the presence of anti-platelet antibodies in the peripheral blood of patients after ischaemic stroke and determine any clinical correlations. Using a flow cytometry-based platelet immunofluorescence method, we detected platelet-reactive antibodies in 15 of 48 (31%) stroke patients and two of 50 (4%) controls (

Indexed as

AgedAutoantibodiesAutoimmunityBlood CoagulationBlood PlateletsBrain IschemiaFemaleHumansIschemic StrokeMalePlatelet AggregationPlatelet CountThrombosisAutoantibodiesanti-platelet antibodiesautoantibodiesneuroprotectionplatelet inhibitionprotective autoimmunitystrokethrombosis

Identifiers

PMID33182365
PMCPMC7664941
OpenAlexW3099045262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.