Evidence map›Paper›PMID 33182332›Full record

ArticleMolecules (Basel, Switzerland)2020

Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson's Disease May Be Related to its Anti-Inflammatory Action.

Hui Lei, Rutong Ren, Yi Sun, Ke Zhang, Xin Zhao, Nuramatjan Ablat, Xiaoping Pu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Frontiers in pharmacology · 2025
    Review
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  9. Article
  10. Heat-killedBioengineering & translational medicine · 2023
    Article
  11. Article
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  13. Article
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  15. Recent progresses in novelFrontiers in bioengineering and biotechnology · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hui LeiDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Rutong RenDepartment of Pharmaceutical Chemistry, Shandong Qidu Pharmaceutical Co., Ltd., Zibo 255400, China.
Yi SunDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0001-7043-5251
Ke ZhangDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Xin ZhaoDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Nuramatjan AblatDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Xiaoping PuDepartment of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-7932-5603
Peking University · CN

Funding

Science and Technology Major Projects: Significant New-Drugs Creation 2018ZX09711001-009-006
6 · The paper itself

Abstract

Safflower (

Indexed as

AnimalsAnti-Inflammatory AgentsApomorphineApoptosisAstrocytesBehavior, AnimalBrainCarthamus tinctoriusCoculture TechniquesDopamineFlavonoidsInflammasomesInflammationInterleukin-1betaMaze LearningMiceAnti-Inflammatory AgentsApomorphineDopamineFlavonoidsIL1B protein, mouseInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOxidopaminePlant ExtractsTyrosine 3-Monooxygenase6-OHDAanti-inflammatory activitiesmouse modelParkinson’s diseasesafflower flavonoid extract

Identifiers

PMID33182332
PMCPMC7664856
OpenAlexW3103740561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.