Evidence map›Paper›PMID 33182279›Full record

ArticleVaccines2020

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies.

Juan Manuel Carreño, Jacqueline U McDonald, Tara Hurst, Peter Rigsby, Eleanor Atkinson, Lethia Charles, Raffael Nachbagauer, Mohammad Amin Behzadi, Shirin Strohmeier, Lynda Coughlan and 16 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Pan-Variant SARS-CoV-2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 7 countries.

Juan Manuel CarreñoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.ORCID 0000-0002-9039-9275
Jacqueline U McDonaldDivision of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar EN6 3QG, UK.
Tara HurstDivision of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar EN6 3QG, UK.
Peter RigsbyDivision of Analytical and Biological Sciences, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar EN6 3QG, UK.
Eleanor AtkinsonDivision of Analytical and Biological Sciences, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar EN6 3QG, UK.
Lethia CharlesDivision of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar EN6 3QG, UK.
Raffael NachbagauerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.
Mohammad Amin BehzadiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.ORCID 0000-0002-1691-6123
Shirin StrohmeierDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.
Lynda CoughlanDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.ORCID 0000-0001-9880-6560
Teresa AydilloDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.ORCID 0000-0003-3086-1058
Boerries BrandenburgJanssen Vaccines & Prevention BV, 2333 CP Leiden, The Netherlands.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.ORCID 0000-0002-6551-1827
Krisztian KaszasJanssen Vaccines & Prevention BV, 2333 CP Leiden, The Netherlands.
Min Z LevineInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Alessandro ManentiVisMederi Research srl, 53100 Siena, Italy.
Adrian B McDermottVaccine Immunology Program (VIP), Vaccine Research Center (VRC), National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Emanuele MontomoliDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Leacky MucheneJanssen Vaccines & Prevention BV, 2333 CP Leiden, The Netherlands.ORCID 0000-0002-5639-4972
Sandeep R NarpalaVaccine Immunology Program (VIP), Vaccine Research Center (VRC), National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Ranawaka A P M PereraSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Nadine C SalischJanssen Vaccines & Prevention BV, 2333 CP Leiden, The Netherlands.ORCID 0000-0002-2951-0800
Sophie A ValkenburgSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Fan ZhouInfluenza Center, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.ORCID 0000-0001-9918-3422
Othmar G EngelhardtDivision of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar EN6 3QG, UK.ORCID 0000-0003-4156-2176
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.ORCID 0000-0003-4121-776X
Icahn School of Medicine at Mount Sinai · USNational Institute for Biological Standards and Control · GBJanssen (Netherlands) · NLNational Institutes of Health · USUniversity of Hong Kong · HKBOKU University · ATCenters for Disease Control and Prevention · USUniversity of Bergen · NOUniversity of Siena · ITVisMederi Research · IT

Funding

Bill & Melinda Gates Foundation OPP1190375
6 · The paper itself

Abstract

The stalk domain of the hemagglutinin has been identified as a target for induction of protective antibody responses due to its high degree of conservation among numerous influenza subtypes and strains. However, current assays to measure stalk-based immunity are not standardized. Hence, harmonization of assay readouts would help to compare experiments conducted in different laboratories and increase confidence in results. Here, serum samples from healthy individuals (

Indexed as

hemagglutinininfluenza vaccineserologystalkstandardization

Identifiers

PMID33182279
PMCPMC7712758
OpenAlexW3104326314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.