ReviewAntioxidants (Basel, Switzerland)2020
Are Flavonoids Effective Antioxidants in Plants? Twenty Years of Our Investigation.
Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
110 citing papers in PubMed, 269 citations in OpenAlex.
- Nematicidal and plant growth-promoting potential of the cell-free culture supernatant of Bacillus megaterium in tomato under Meloidogyne incognita infection: an in vitro and in vivo study.Archives of microbiology · 2026Article
- Infection with Tomato Mosaic Virus inInternational journal of molecular sciences · 2026Article
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- Phenolic Composition and Antioxidant Capacity in Table Grape Berries Following Natural Hail Damage.International journal of molecular sciences · 2026Article
- Molecular and physiological characterization of two sunflower near-isogenic lines with contrasting haplotypes for leaf senescence.BMC plant biology · 2026Article
- LlR3MYB-mediated flavonoid biosynthesis confers cold stress tolerance inHorticulture research · 2026Article
- The Chemical Structures, Neuroprotective Effects, Structure-Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review.Food science & nutrition · 2026Review
- Diversity in seed fatty acid composition and petal pyrrolizidine alkaloid content in Echium amoenum Fisch. & C.A.Mey. populations.BMC plant biology · 2026Article
- Effect of Drying and Cooking on the Chemical Composition, Phenolic Profile, and Antioxidant Capacity ofPlants (Basel, Switzerland) · 2026Article
- Boundary-line trade-off in bryophytes between UV photoprotection and photosynthetic capacity, but not desiccation tolerance.Annals of botany · 2026Article
- Molecular Mimicry Inference, Therapeutic Target Identification, and Natural Product Inhibition Study inACS omega · 2026Article
- Formation of Adaptive Defense to Low Temperatures in Arabidopsis thaliana.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026Article
- Terrestrial Plant- and Algal-Derived Biostimulants as Modulators of ROS and Hormone Networks in Crop Abiotic Stress Resilience.Plants (Basel, Switzerland) · 2026Review
- Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance.World journal of gastroenterology · 2026Review
- The Antimicrobial and Cytotoxicity Properties of New Dibrominated 1,3-Dithiolium Flavonoids.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Altitude-Dependent Differences in Non-Volatile Metabolites of Tea Leaves Revealed by Widely Targeted Metabolomics.Biology · 2026Article
- Gibberellic Acid-Induced Regulation of Antioxidant-Flavonoid Channels Provides Protection Against Oxidative Damage in Safflower Under Salinity Stress.Plants (Basel, Switzerland) · 2026Article
- Flavonoids in Plant Salt Stress Responses: Biosynthesis, Regulation, Functions, and Signaling Networks.Plants (Basel, Switzerland) · 2026Review
- A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming.Frontiers in plant science · 2026Review
- Effects of moisture-preserving yellowing process optimization on cell physiology and post-curing chemical composition.BMC plant biology · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether flavonoids play significant antioxidant roles in plants challenged by photooxidative stress of different origin has been largely debated over the last few decades. A critical review of the pertinent literature and our experimentation as well, based on a free-of-scale approach, support an important antioxidant function served by flavonoids in plants exposed to a wide range of environmental stressors, the significance of which increases with the severity of stress. On the other side, some questions need conclusive answers when the putative antioxidant functions of plant flavonoids are examined at the level of both the whole-cell and cellular organelles. This partly depends upon a conclusive, robust, and unbiased definition of "a plant antioxidant", which is still missing, and the need of considering the subcellular re-organization that occurs in plant cells in response to severe stress conditions. This likely makes our deterministic-based approach unsuitable to unveil the relevance of flavonoids as antioxidants in extremely complex biological systems, such as a plant cell exposed to an ever-changing stressful environment. This still poses open questions about how to measure the occurred antioxidant action of flavonoids. Our reasoning also evidences the need of contemporarily evaluating the changes in key primary and secondary components of the antioxidant defense network imposed by stress events of increasing severity to properly estimate the relevance of the antioxidant functions of flavonoids in an in planta situation. In turn, this calls for an in-depth analysis of the sub-cellular distribution of primary and secondary antioxidants to solve this still intricate matter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.