Evidence map›Paper›PMID 33181677›Full record

ArticleMedicine2020

Treatment of primary biliary cirrhosis with ursodeoxycholic acid combined with traditional Chinese medicine: A protocol for systematic review and meta analysis.

Xing Chen, Xiao Ma, Ruilin Wang, Lifu Wang, Jianyu Li, Honghong Liu, Tingting He, Shizhang Wei, Haotian Li, Min Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xing ChenDepartment of Pharmacy, Chinese PLA General Hospital, Beijing.ORCID 0000-0003-1489-4167
Xiao MaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu.
Ruilin WangIntegrative Medical Center, Chinese PLA General Hospital, Beijing, China.
Lifu WangIntegrative Medical Center, Chinese PLA General Hospital, Beijing, China.
Jianyu LiIntegrative Medical Center, Chinese PLA General Hospital, Beijing, China.
Honghong LiuIntegrative Medical Center, Chinese PLA General Hospital, Beijing, China.
Tingting HeIntegrative Medical Center, Chinese PLA General Hospital, Beijing, China.
Shizhang WeiDepartment of Pharmacy, Chinese PLA General Hospital, Beijing.
Haotian LiDepartment of Pharmacy, Chinese PLA General Hospital, Beijing.
Min WangDepartment of Pharmacy, Chinese PLA General Hospital, Beijing.
Yanling ZhaoDepartment of Pharmacy, Chinese PLA General Hospital, Beijing.
Chinese PLA General Hospital · CNChengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUrsodeoxycholic acid is the priority drug of primary biliary cirrhosis (PBC) and is usually combined with traditional Chinese medicine. This study aimed to systematically evaluate the benefits of integrated Chinese and western interventions for PBC.

methodsSearched the randomized controlled trials in PubMed, Web of Science, CNKI, CBM, Wanfang, VIP databases. The Cochrane risk of bias tool was used for methodological quality assessment and all data analysis was performed using Revman5.3 and Stata14.2 software.

result30 randomized controlled trials involving 10 interventions with a total of 1948 participants were included. Identified the direct and indirect evidence of trials, and used network meta analyses ranked the benefits of different interventions based on pairwise meta analysis. The primary outcom was clinical efficacy rate. Secondary outcome was liver function, including alkaline phosphataseand total bilirubin.

conclusionThe conclusion of this systematic review provide credible evidence - based for the relative advantages of integrated Chinese and western interventions for PBC.

Indexed as

Cholagogues and CholereticsCombined Modality TherapyHumansLiver Cirrhosis, BiliaryMedicine, Chinese TraditionalMeta-Analysis as TopicResearch DesignSystematic Reviews as TopicTreatment OutcomeUrsodeoxycholic AcidCholagogues and CholereticsUrsodeoxycholic Acid

Identifiers

PMID33181677
PMCPMC7668450
OpenAlexW3100567060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.