Evidence map›Paper›PMID 33181475›Full record

ArticlePregnancy hypertension2021

Gestational weight gain and adverse pregnancy outcomes by pre-pregnancy BMI category in women with chronic hypertension: A cohort study.

Sylvia E Badon, Sascha Dublin, Nerissa Nance, Monique M Hedderson, Romain Neugebauer, Thomas Easterling, T Craig Cheetham, Lu Chen, Victoria L Holt, Lyndsay A Avalos

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Pregnancy hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  7. Dietary factors that affect the risk of pre-eclampsia.BMJ nutrition, prevention & health · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sylvia E BadonKaiser Permanente Northern California Division of Research, Oakland, CA, United States. Electronic address: sylvia.e.badon@kp.org.
Sascha DublinKaiser Permanente Washington Health Research Institute, Seattle, WA, United States.
Nerissa NanceKaiser Permanente Northern California Division of Research, Oakland, CA, United States.
Monique M HeddersonKaiser Permanente Northern California Division of Research, Oakland, CA, United States.
Romain NeugebauerKaiser Permanente Northern California Division of Research, Oakland, CA, United States.
Thomas EasterlingUniversity of Washington Department of Obstetrics and Gynecology, Seattle, WA, United States.
T Craig CheethamChapman University School of Pharmacy, Irvine, CA, United States.
Lu ChenKaiser Permanente Washington Health Research Institute, Seattle, WA, United States.
Victoria L HoltUniversity of Washington Department of Epidemiology, Seattle, WA, United States.
Lyndsay A AvalosKaiser Permanente Northern California Division of Research, Oakland, CA, United States.
Kaiser Permanente · USKaiser Permanente Washington Health Research Institute · USUniversity of Washington · USChapman University · US

Funding

Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Moderate Hypertension in Pregnancy: Safety and Effectiveness of TreatmentR01HD082141 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI DUBLIN, SASCHA · 2015 to 2018
$3.8M
T32 Training Program in Diabetes Translational ResearchT32DK116684 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GRANT, RICHARD W, SCHMITTDIEL, JULIE A · 2018 to 2022
$714k
Using a 24-Hour Movement Framework to Improve Pregnancy OutcomesK99HD100585 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI BADON, SYLVIA E · 2020 to 2021
$280k
NICHD NIH HHS K99 HD100585NICHD NIH HHS R01 HD082141NIDDK NIH HHS P30 DK092924NIDDK NIH HHS T32 DK116684
6 · The paper itself

Abstract

objectivesIt is important to understand relationships of gestational weight gain with adverse pregnancy outcomes in women with chronic hypertension, given their high baseline risk of adverse outcomes. We assessed associations of gestational weight gain with adverse pregnancy outcomes in women with chronic hypertension by pre-pregnancy body mass index categories. STUDY

designWe identified 14,369 women with chronic hypertension using electronic health records from 3 integrated health care delivery systems (2005-2014). Gestational weight gain-for-gestational age charts were used to calculate gestational weight gain z-scores, which account for gestational age. Modified Poisson regression models using generalized estimating equations were used to calculate relative risks and 95% confidence intervals, adjusted for sociodemographic and medical characteristics. MAIN OUTCOME MEASUREMENTS: Preeclampsia, preterm delivery, cesarean delivery, neonatal intensive care unit admission, birthweight (extracted from the electronic health record).

resultsIn women with normal weight or overweight, low gestational weight gain (z-score < -1) was associated with 27-28% greater risk of preterm delivery and 48-82% greater risk of small-for-gestational age birthweight, while high gestational weight gain (z-score > 1) was associated with 40-90% greater risk of preeclampsia and 59-113% greater risk of large-for-gestational age birthweight. In women with obesity, low gestational weight gain was associated with 27-54% lower risk of several adverse pregnancy outcomes, including preeclampsia and cesarean delivery.

conclusionsIn women with chronic hypertension and normal weight or overweight, moderate gestational weight gain may confer the lowest risk of adverse outcomes. In women with chronic hypertension and obesity, low gestational weight gain may be necessary for the lowest risk of adverse pregnancy outcomes.

Indexed as

Body Mass IndexGestational Weight GainAdultBirth WeightCesarean SectionFemaleHumansHypertensionInfant, NewbornIntensive Care Units, NeonatalObesityPre-EclampsiaPregnancyPremature BirthRetrospective StudiesRisk AssessmentBirthweightCesareanGestational weight gainNeonatal intensive care unitPreeclampsiaPreterm birth

Identifiers

PMID33181475
PMCPMC7904620
OpenAlexW3094378861

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.