ArticleInternational journal of hygiene and environmental health2021
Per- and polyfluoroalkyl substance mixtures and gestational weight gain among mothers in the Health Outcomes and Measures of the Environment study.
Article in International journal of hygiene and environmental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Quantifying PFAS-Omics Burden Scores for Nontargeted Analysis Using Multidimensional Item Response Theory: An Exploratory Analysis of Novel and Legacy PFAS in Cord Blood.Environmental science & technology · 2026Article
- Per- and polyfluoroalkyl substances serum concentrations during pregnancy and gestational weight gain in the Healthy Start Study.International journal of hygiene and environmental health · 2026Article
- Organophosphate ester exposure in pregnancy, gestational weight gain, and postpartum body composition in a U.S.-based longitudinal pregnancy cohort.Environmental health : a global access science source · 2025Article
- Evaluation and comparison of tools used to quantify aggregate PFAS exposure: Extractable organic fluorine, PFAS burden scores and summed PFAS concentrations.Journal of exposure science & environmental epidemiology · 2025Article
- Associations of prenatal per- and polyfluoroalkyl substances with whole blood folate levels in pregnant women in the Health Outcomes and Measures of the Environment (HOME) Study.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Intergenerational metabolic toxicity of perfluorooctanesulfonic acid exposure in adult offspring rats: a multi-omics approach.Frontiers in endocrinology · 2025Article
- Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances and Gestational Weight Gain: A Systematic Review and Meta-analysis.International journal of preventive medicine · 2025Review
- Considerations for Measurements of Aggregate PFAS Exposure in Precision Environmental Health.ACS measurement science au · 2024Review
- Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort.Environmental health : a global access science source · 2023Article
- Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation.Nature communications · 2023Article
- Article
- Prenatal perfluoroalkyl substances exposure and maternal sex steroid hormones across pregnancy.Environmental research · 2023Article
- Gestational exposure to organophosphate esters and infant anthropometric measures in the first 4 weeks after birth.The Science of the total environment · 2023Article
- Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study.Environmental pollution (Barking, Essex : 1987) · 2023Article
- C57BL/6J mice exposed to perfluorooctanoic acid demonstrate altered immune responses and increased seizures after Theiler's murine encephalomyelitis virus infection.Frontiers in immunology · 2023Article
- Maternal urinary organophosphate ester metabolite concentrations and glucose tolerance during pregnancy: The HOME Study.International journal of hygiene and environmental health · 2022Article
- Obesity II: Establishing causal links between chemical exposures and obesity.Biochemical pharmacology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundPer- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals commonly used in the production of household and consumer goods. While exposure to PFAS has been associated with greater adiposity in children and adults, less is known about associations with gestational weight gain (GWG).
methodsWe quantified using mass spectrometry perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS) and perfluorononanoate (PFNA) in maternal serum from 18 ± 5 weeks' gestation (mean ± standard deviation (std)) in a prospective pregnancy and birth cohort (2003-2006, Cincinnati, Ohio) (n = 277). After abstracting weight data from medical records, we calculated GWG from 16 ± 2 weeks' gestation (mean ± std) to the measured weight at the last visit or at delivery, rate of weight gain in the 2nd and 3rd trimesters (GWR), and total weight gain z-scores standardized for gestational age at delivery and pre-pregnancy BMI. We investigated covariate-adjusted associations between individual PFAS using multivariable linear regression; we assessed potential effect measure modification (EMM) by overweight/obese status (pre-pregnancy BMI<25 kg/m
resultsEach doubling in serum concentrations of PFOA, PFOS, and PFNA was associated with a small increase in GWG (range 0.5-0.8 lbs) and GWR (range 0.03-0.05 lbs/week) among all women. The association of PFNA with GWG was stronger among women with BMI≥25 kg/m
conclusionAlthough there were consistent small increases in gestational weight gain with increasing PFOA, PFOS, and PFNA serum concentrations in this cohort, the associations were imprecise. Additional investigation of the association of PFAS with GWG in other cohorts would be informative and could consider pre-pregnancy BMI as a potential modifier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.