Evidence map›Paper›PMID 33181340›Full record

ArticleThe journal of allergy and clinical immunology. In practice2021

Diabetes Mellitus Is Associated with Worse Outcome in Patients Hospitalized for Asthma.

Peng Zhang, Rocio Lopez, Amy H Attaway, Steve N Georas, Sumita B Khatri, Simon Abi-Saleh, Joe G Zein

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Hospitalization Outcomes of Patients with Asthma, COPD, and Asthma-COPD Overlap Syndrome.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Hormonal Effects on Asthma, Rhinitis, and Eczema.The journal of allergy and clinical immunology. In practice · 2022
    Review
  11. Nonrespiratory Comorbidities in Asthma.The journal of allergy and clinical immunology. In practice · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng ZhangRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Rocio LopezCenter for Populations Health Research, Cleveland Clinic, Cleveland, Ohio; Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Amy H AttawayRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Steve N GeorasDepartment of Medicine, University of Rochester Medical Center, Rochester, NY.
Sumita B KhatriRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Simon Abi-SalehRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Joe G ZeinRespiratory Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: zeinj@ccf.org.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI B Paige Lawrence · 1985 to 2026
$42.8M
Gender-based precision care for asthmaK08HL133381 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZEIN, JOE · 2017 to 2021
$836k
NHLBI NIH HHS K08 HL133381NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

backgroundAsthma is a prevalent disease with a high economic cost. More than 50% of its direct cost relates to asthma hospitalizations. Diabetes mellitus (DM) is a significant comorbidity in asthmatic patients, yet its impact on asthma-related hospitalizations is unknown.

objectiveTo compare the outcome of asthma-related hospitalizations in patients with and without DM.

methodsUsing Healthcare Cost and Utilization Project Nationwide Readmissions Database, we analyzed data of all adults with index admission for asthma and with no other chronic pulmonary conditions, and compared outcomes between patients with and without DM. Weighted regression analysis was used to determine the impact of DM on hospitalization outcomes. All multivariate regression models were adjusted for patient demographics, socioeconomic status, and chronic medical comorbidities.

resultsA total of 717,200 asthmatic patients were included, with 202,489 (28.3%) having DM. Diabetic patients were older and had more comorbidities. When hospitalized for asthma, diabetic patients had increased hospital length of stay, cost, and risk for 30-day all-cause and asthma-related readmission. They also had a higher risk for developing nonrespiratory complications during their hospital stay compared with nondiabetic patients. The risk of mortality was similar between the 2 groups.

conclusionsPatients hospitalized for asthma with coexisting DM had increased hospital length of stay, cost, and risk for readmission. Interventions are urgently needed to reduce the risk for hospital admission and readmission in patients with coexisting DM and asthma. These interventions would have profound economic and societal impact.

Indexed as

AsthmaDiabetes MellitusAdultComorbidityHealth Care CostsHospitalizationHumansLength of StayRetrospective StudiesAsthmaCostDiabetes mellitusLength of stayReadmission

Identifiers

PMID33181340
PMCPMC8043963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.