ArticlePharmacological research2020
Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: A retrospective multicenter cohort study.
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Article in Pharmacological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Status and hotspot analysis of Qingfei Paidu Decoction for the prevention and treatment of COVID-19 based on bibliometric analysis.Frontiers in pharmacology · 2024Pooled it
- Effect of Qingfei Paidu decoction combined with Western medicine treatments for COVID-19: A systematic review and meta-analysis.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2022Pooled it
- Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2022Pooled it
- Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts.Journal of ethnopharmacology · 2021Pooled it
- Molecular Compatibility in Chinese Medicine for Cancer Treatment and Drug Development: From Traditional Wisdom to Innovative Therapeutics.Chinese journal of integrative medicine · 2026Article
- A Machine Learning Approach to Differentiate Cold and Hot Syndrome in Viral Pneumonia Integrating Traditional Chinese Medicine and Modern Medicine: Machine Learning Model Development and Validation.JMIR medical informatics · 2025Article
- Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D.Natural products and bioprospecting · 2025Article
- Scutellaria barbata D. Don extracts alleviate SARS-CoV-2 induced acute lung injury by inhibiting virus replication and bi-directional immune modulation.Virologica Sinica · 2025Article
- Ethnobotanical survey of herbal medicines for anti-COVID-19 used by traditional Chinese medicine pharmacies in Taiwan.Frontiers in pharmacology · 2025Article
- Chinese Medicine for Treatment of COVID-19: A Review of Potential Pharmacological Components and Mechanisms.Chinese journal of integrative medicine · 2025Review
- Effectiveness of Five-Element Regulatory Therapy for post-COVID syndrome: a retrospective cohort study.Frontiers in medicine · 2025Article
- Fuzheng Jiedu granules against disease progression among high-risk adults with non-severe COVID-19: a multicenter retrospective cohort study.Frontiers in pharmacology · 2025Article
- Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets.Pharmaceutical biology · 2023Review
- Recent advances in anti-inflammatory active components and action mechanisms of natural medicines.Inflammopharmacology · 2023Review
- Long-term effects of Qingfei Paidu decoction in patients with coronavirus disease 2019 acute pneumonia after treatment: a protocol for systematic review and Meta-analysis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Bioinformatic assay reveal the potential mechanism of Guizhi-Shaoyao-Zhimu decoction against rheumatoid arthritis and mild-to-moderate COVID-19.Computer methods and programs in biomedicine · 2023Article
- Systems pharmacology dissection of pharmacological mechanisms of Xiaochaihu decoction against human coronavirus.BMC complementary medicine and therapies · 2023Article
- Liver in infections: a single-cell and spatial transcriptomics perspective.Journal of biomedical science · 2023Review
- Potential herb‒drug interactions between anti-COVID-19 drugs and traditional Chinese medicine.Acta pharmaceutica Sinica. B · 2023Review
- Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2.American journal of respiratory cell and molecular biology · 2023Article
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Authors and funding
92 authors.
Nannan ShiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Bin LiuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Ning LiangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Yan MaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Youwen GeInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Honggang YiSchool of Public Health, Nanjing Medical University, Nanjing, China.
Hongmei WoSchool of Health Policy and Management, Nanjing Medical University, Nanjing, China.
Heng GuSchool of Public Health, Nanjing Medical University, Nanjing, China.
Yuan KuangSchool of Public Health, Nanjing Medical University, Nanjing, China.
Shaowen TangSchool of Public Health, Nanjing Medical University, Nanjing, China.
Yang ZhaoSchool of Public Health, Nanjing Medical University, Nanjing, China.
Lin TongInstitute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Sihong LiuInstitute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Chen ZhaoInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Renbo ChenInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Weiguo BaiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Yipin FanInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Zhan ShiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Li LiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Jia LiuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Hao GuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Yingjie ZhiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Zhifei WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Yuanyuan LiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Huizhen LiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Jingya WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Liwen JiaoInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Yaxin TianInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Yibai XiongInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Ruili HuoChina Academy of Chinese Medical Sciences, Beijing, China.
Xiaohui ZhangInstitute of Medical Information, Chinese Academy of Medical Science, Beijing, China.
Jiangfeng BaiDepartment of Infectious Disease, Yulin Chinese Medicine Hospital, Shaanxi, China.
Hong ChenPresident's Office, The First Hospital of Qiqiha, Heilongjiang, China.
Liying ChenDepartment of Traditional Chinese Medicine, Shangluo Central Hospital, Shaanxi, China.
Qiao FengDepartment of Traditional Chinese Medicine, The People's Hospital of QiTaiHe, Heilongjiang, China.
Tuanmao GuoDepartment of Scientific Research, Xianyang Central Hospital, Shaanxi, China.
Yong HouThe First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Anhui, China.
Guifen HuDepartment of Infectious Disease, HePing Hospital Affiliated to ChangZhi Medical College, Shanxi, China.
Xiaomei HuDepartment of Traditional Chinese Medicine, Langfang Hospital of Chinese Medicine, Hebei, China.
Yunhong HuDepartment of Traditional Chinese Medicine, Xingtai Hospital of Chinese Medicine, Hebei, China.
Jin HuangDepartment of Traditional Chinese Medicine, The People's Hospital of GuangXi Zhuang Autonomous Region, Guangxi, China.
Qiuhua HuangDepartment of Traditional Chinese Medicine, The People's Hospital of GuangXi Zhuang Autonomous Region, Guangxi, China.
Shaozhen HuangDepartment of Traditional Chinese Medicine, The First People's Hospital of Fangchenggang, Guangxi, China.
Liang JiDepartment of Traditional Chinese Medicine, Mianyang Hospital of Traditional Chinese Medicine, Sichuan, China.
Haihao JinDepartment of Traditional Chinese Medicine, Liuzhou People's Hospital, Guangxi, China.
Xiao LeiDepartment of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.
Chunyan LiDepartment of Infectious Disease, Yan'an Second People's Hospital, Shaanxi, China.
Guihui WuDepartment of Traditional Chinese Medicine, The Public Health Clinical Center of Chengdu, Sichuan, China.
Jike LiDepartment of Traditional Chinese Medicine, The Public Health Clinical Center of Chengdu, Sichuan, China.
Minqing LiDepartment of Traditional Chinese Medicine, Dazhou Central Hospital, Sichuan, China.
Quntang LiChongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Xianyong LiThe Second People's Hospital of Neijiang, Sichuan, China.
Hongde LiuShijiazhuang Fifth Hospital, Hebei, China.
Jinping LiuDepartment of Infectious Disease, The Fourth People's Hospital of Taiyuan, Shanxi, China.
Zhang LiuDepartment of Traditional Chinese Medicine, The First Hospital of Suihua City, Heilongjiang, China.
Yuting MaDepartment of Traditional Chinese Medicine, The Fourth People's Hospital of Nanning, Guangxi, China.
Ya MaoDepartment of Infectious Disease, Ankang Hospital of Traditional Chinese Medicine, Shaanxi, China.
Liufen MoBeihai Hospital of Chinese Medicine, Guangxi, China.
Hui NaDepartment of Infectious Disease, Harbin Infectious Disease Hospital, Heilongjiang, China.
Jingwei WangDepartment of Infectious Disease, Harbin Infectious Disease Hospital, Heilongjiang, China.
Fangli SongDepartment of Infectious Disease, The Third People's Hospital of Linfen, Shanxi, China.
Sheng SunDepartment of Traditional Chinese Medicine, Chengde Hospital of Traditional Chinese Medicine, Hebei, China.
Dongting WangDepartment of Infectious Disease, Datong Fourth Hospital, Shanxi, China.
Mingxuan WangDepartment of Traditional Chinese Medicine, Suining Central Hospital, Sichuan, China.
Xiaoyan WangDepartment of Infectious Disease, Jinzhong Infectious Disease Hospital, Shanxi, China.
Yinzhen WangDepartment of Infectious Disease, Jincheng People's Hospital, Shanxi, China.
Yudong WangHengshui Hospital of Chinese Medicine, Hebei, China.
Wei WuPresident's Office, Hanzhong Central Hospital, Shaanxi, China.
Lanping WuDepartment of Infectious Disease, Shuozhou People's Hospital, Shanxi, China.
Yanhua XiaoDepartment of Traditional Chinese Medicine, Mudanjiang Kangan Hospital, Heilongjiang, China.
Haijun XieDepartment of Infectious Disease, Xinzhou People's Hospital, Shanxi, China.
Hongming XuDepartment of Infectious Disease, Daqing Second Hospital, Heilongjiang, China.
Shoufang XuJiamusi Infectious Disease Hospital, Heilongjiang, China.
Ruixia XueDepartment of Infectious Disease, Yuncheng Second Hospital, Shanxi, China.
Chun YangDepartment of Traditional Chinese Medicine, Hanzhong Hospital for Infectious Diseases, Shaanxi, China.
Kaijun YangDepartment of Medical Administration, The Third People's Hospital of Yangquan, Shanxi, China.
Puye YangDepartment of Infectious Disease, Shaanxi Infectious Disease Hospital, Shaanxi, China.
Shengli YuanDepartment of Traditional Chinese Medicine, Zhangjiakou Hospital of Traditional Chinese Medicine, Hebei, China.
Gongqi ZhangDepartment of Traditional Chinese Medicine, Baoji Central Hospital, Shaanxi, China.
Jinbo ZhangDepartment of Infectious Disease, Xi'an Chest Hospital, Shaanxi, China.
Linsong ZhangDepartment of Traditional Chinese Medicine, Hospital (T·C·M) Affiliated to Southwest Medical University, Sichuan, China.
Shusen ZhaoQiqihar Institute for The Prevention and Treatment of Infectious Diseases, Heilongjiang, China.
Wanying ZhaoHegang Infectious Hospital, Heilongjiang, China.
Kai ZhengFenyang Hospital of Shanxi Province, Shanxi, China.
Yingchun ZhouDepartment of Infectious Disease, Shuangyashan People's Hospital, Heilongjiang, China.
Junteng ZhuDepartment of Rehabilitation Medicine, The Affiliated Hospital of Putian College, Fujian, China.
Tianqing ZhuDepartment of Infectious Disease, The Greater Khingan Range People's Hospital, Heilongjiang, China.
Guangxi LiGuang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: lgx0410@163.com.
Wei WangBeijing University of Chinese Medicine, Beijing, China. Electronic address: wangwei26960@126.com.
Huamin ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: zhanghm@mail.cintcm.ac.cn.
Yanping WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: wangyanping4816@163.com.
Yongyan WangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: wangyongyan1938@126.com.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between early treatment with Qingfei Paidu decoction (QFPDD) and favorable clinical outcomes. In this retrospective multicenter study, we included 782 patients (males, 56 %; median age 46) with confirmed COVID-19 from 54 hospitals in nine provinces of China, who were divided into four groups according to the treatment initiation time from the first date of onset of symptoms to the date of starting treatment with QFPDD. The primary outcome was time to recovery; days of viral shedding, duration of hospital stay, and course of the disease were also analyzed. Compared with treatment initiated after 3 weeks, early treatment with QFPDD after less than 1 week, 1-2 weeks, or 2-3 weeks had a higher likelihood of recovery, with adjusted hazard ratio (HR) (95 % confidence interval [CI]) of 3.81 (2.65-5.48), 2.63 (1.86-3.73), and 1.92 (1.34-2.75), respectively. The median course of the disease decreased from 34 days to 24 days, 21 days, and 18 days when treatment was administered early by a week (P < 0.0001). Treatment within a week was related to a decrease by 1-4 days in the median duration of hospital stay compared with late treatment (P<0.0001). In conclusion, early treatment with QFPDD may serve as an effective strategy in controlling the epidemic, as early treatment with QFPDD was associated with favorable outcomes, including faster recovery, shorter time to viral shedding, and a shorter duration of hospital stay. However, further multicenter, prospective studies with a larger sample size should be conducted to confirm the benefits of early treatment with QFPDD.
Indexed as
COVID-19 Drug TreatmentAdultAgedAged, 80 and overChinaCohort StudiesDrugs, Chinese HerbalFemaleFollow-Up StudiesHumansLength of StayMaleMiddle AgedTime-to-TreatmentTreatment OutcomeYoung AdultDrugs, Chinese Herbalqingfei paidu decoctionCOVID-19Early treatmentQingfei Paidu decoction
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