Evidence map›Paper›PMID 33181139›Full record

ArticleThe American journal of pathology2021

In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene.

Lisa G Lanigan, Blake E Hildreth, Wessel P Dirksen, Jessica K Simmons, Chelsea K Martin, Jillian L Werbeck, Nandu K Thudi, Tracey L Papenfuss, Prosper N Boyaka, Ramiro E Toribio and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Lisa G LaniganDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio; Tox Path Specialists, a StageBio Company, Fredrick, Maryland.
Blake E HildrethDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Wessel P DirksenDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Jessica K SimmonsDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Chelsea K MartinDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio; Department of Pathology and Microbiology, University of Prince Edward Island, Atlantic Veterinary College, Prince Edward Island, Canada.
Jillian L WerbeckDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Nandu K ThudiDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Tracey L PapenfussDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Prosper N BoyakaDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Ramiro E ToribioDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Jerrold M WardGlobal VetPathology, Montgomery Village, Maryland.
Katherine N WeilbaecherDivision of Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Thomas J RosolDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio. Electronic address: rosolt@ohio.edu.
The Ohio State University · USGlobal VetPathology · USOhio University · USUniversity of Alabama at Birmingham · USUniversity of Prince Edward Island · CAWashington University in St. Louis · US

Funding

Role of Inflammation in Tax-mediated TumorigenesisP01CA100730 · NCI · WASHINGTON UNIVERSITY · PI Lee Ratner · 2003 to 2026
$44.8M
MOUSE PATHOBIOLOGY: MODELS OF HUMAN DISEASET32RR007073 · NCRR · OHIO STATE UNIVERSITY · PI ROSOL, THOMAS J · 2002 to 2011
$3.2M
Macrophage and osteoclast specific targeting for the prevention and treatment of breast cancer bone metastasisK01OD026527 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HILDRETH, BLAKE EASON · 2018 to 2022
$634k
NCI NIH HHS P01 CA100730NCRR NIH HHS T32 RR007073NIH HHS K01 OD026527
6 · The paper itself

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia, a disease commonly associated with hypercalcemia and osteolysis. There is no effective treatment for HTLV-1, and the osteolytic mechanisms are not fully understood. Mice expressing the HTLV-1 oncogene Tax, driven by the human granzyme B promoter (Tax

Indexed as

Cell Line, TumorDisease Models, AnimalGenes, pXHistiocytic SarcomaAnimalsCarcinogenesisHTLV-I InfectionsHumansHuman T-lymphotropic virus 1MiceMice, Inbred C57BLMice, TransgenicOncogenesOsteolysis

Identifiers

PMID33181139
PMCPMC7863134
OpenAlexW3100541733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.