ReviewJornal de pediatria
Immune system: development and acquisition of immunological competence.
Review in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Article
- Differential cytokine signature profiles in neonates, infants, and children with enterovirus meningitis.Journal of virology · 2026Observational
- Bacterial-Derived Immunomodulators as a Preventive Strategy for Viral Respiratory Tract Infections and Associated Wheezing or Asthma in Children: A Targeted Narrative Review.Children (Basel, Switzerland) · 2026Review
- Distinct infant resistome trajectories shaped by country income and geography revealed through global metagenomics reanalysis.npj antimicrobials and resistance · 2026Article
- Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm.Pharmacoepidemiology and drug safety · 2026Article
- Causal effects of breastfeeding promotion on child health: understanding the role of nutrition.Swiss journal of economics and statistics · 2026Article
- Childhood appendectomy is linked with higher digestive, respiratory, and genitourinary disease risk but lower inflammatory bowel disease risk.Evolution, medicine, and public health · 2026Article
- HIDmap: a physiology-based map of human immune system development to support animal-free research and regulatory innovation.Frontiers in immunology · 2026Article
- Analysis of Plasma Biomarkers and Potential Pathogenesis in Children withInfection and drug resistance · 2026Article
- Temporal patterns and risk factors of diarrheal comorbidity among children aged < 5 years in rural western Kenya: Evidence from three consecutive enteric studies, 2008-2024.PLOS global public health · 2026Article
- Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.Research square · 2025Article
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Network analysis reveals protein modules associated with childhood respiratory diseases.The Journal of allergy and clinical immunology · 2025Article
- Nutritional Deficiencies and Oral Candidiasis in Children from Northeastern Romania: A Cross-Sectional Biochemical Assessment.Nutrients · 2025Observational
- Adverse Events FollowingVaccines · 2025Article
- Acute Respiratory Tract Infections in Pediatric Populations of Slum Areas: Navigating Challenges and Dynamics of Immune Responses.Current pediatric reviews · 2025Review
- Distinct immune profiles in children living with HIV based on timing and duration of suppressive antiretroviral treatment.Virology · 2025Article
- The influence of immune regulation mediated by intestinal microbiota on postmenopausal osteoporosis and intervention strategies.Frontiers in endocrinology · 2025Review
- Effect of Delayed Cord Clamping on Respiratory Infection-Related Encounters in the First 6 Months of Life in an Urban Community Hospital.International journal of pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe the ontogeny of the immune system and the adaptive mechanisms of the immune system in the neonatal period, with an emphasis on transplacental antibody transport and breastfeeding. SOURCE OF DATA: Non-systematic literature review in the PubMed database. SUMMARY OF THE
findingsThe last two decades have witnessed a great advance in the knowledge of the immune system since conception. Several investigation tools have provided insight on phenomena that were previously inadequately understood. Still expanding, the functional and molecular investigation of various aspects of the immune system will make it possible to understand how intra-uterus maternal-fetal exchanges, the maternal microbiota interacting with the fetus and newborn, and the acquisition of immunological competence occur in healthy and disease scenarios.
conclusionsIn-depth knowledge of the development of the immune system and of the adaptive mechanisms that allow a safer transition to the extrauterine environment are fundamental components of optimizing maternal and young infant vaccination, as well as the strategies associated with full postnatal development, and the early diagnosis and treatment of innate errors of immunity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.