ArticleNeuron2021
Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury.
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Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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105 citing papers in PubMed, 187 citations in OpenAlex.
- Global and regional amyloid-β in explaining APOE-ε4 and sex associations with medial temporal tau: a neuropathology study.Acta neuropathologica · 2026Article
- Targeting Spinal Dorsal Horn Sensitisation in Chronic Pain: Mechanisms and Translational Strategies.Neuroscience bulletin · 2026Review
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- Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain.Nature communications · 2026Article
- Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice.Nature communications · 2026Article
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- TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.Signal transduction and targeted therapy · 2026Article
- Microglia-Mediated Dysfunction of PKCγ Interneurons Underlies the Mechanical Hypersensitivity in Autism.Molecular neurobiology · 2026Article
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- Spinal Processing of Spatiotemporally Diverse Tactile Stimuli: Computational Insights into Allodynia and Spinal Cord Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Kv4.3 channel on c-low threshold mechanoreceptors in DRG is a key mediator transforming tactile stimuli into nociceptive signals in chemotherapy-induced neuropathy.Acta pharmaceutica Sinica. B · 2026Article
- Dorsal root ganglion neuromodulation restores accumbal gate to inhibit mechanical allodynia.The journal of headache and pain · 2026Article
- Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia.Cell reports · 2026Article
- Spatial transcriptomics reveals organizational properties of mouse spinal cord and alterations in neuropathic pain.bioRxiv : the preprint server for biology · 2026Article
- Ontogeny of the spinal cord dorsal horn.Science (New York, N.Y.) · 2026Article
- The intrinsic reason why the term "central sensitization" should be refined, by introducing the terms "spinal sensitization", "pain-related brain network sensitization", and "psychosocial-related sensitization".Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Molecularly diverse glycinergic interneurons in the medial deep dorsal horn are interposed between primary sensory afferents and spinal Shox2 interneurons.Frontiers in neural circuits · 2026Article
- Cannabidiol/cannabigerol exposure and neuropathy-related outcomes after neurotoxic chemotherapy: a real-world cohort study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
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- GPR37 activation erases spinal pain memory and resolves increased nociception in murine models.bioRxiv : the preprint server for biology · 2025Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 2 institutions in 1 country.
Cedric PeirsDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Sean-Paul G WilliamsDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Xinyi ZhaoDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Cynthia M ArokiarajDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
David W FerreiraDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Myung-Chul NohDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Kelly M SmithDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Priyabrata HalderDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Kelly A CorriganDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Jeremy Y GedeonDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Suh Jin LeeDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Graziana GattoMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA.
David ChiDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Sarah E RossDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Martyn GouldingMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA.
Rebecca P SealDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA. Electronic address: rpseal@pitt.edu.
University of Pittsburgh · USSalk Institute for Biological Studies · US
Funding
Spinal circuits for mechanical itch and light touchR35NS111643 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Martyn D Goulding · 2019 to 2026
$9.7MPredoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0MInvestigating the Neural Circuits of ItchR01AR063772 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI H Richard Koerber, Sarah Elizabeth Ross · 2013 to 2026
$6.9MMolecular genetic dissection of the spinal microcircuits of wind-upR01NS096705 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD, ROSS, SARAH ELIZABETH · 2016 to 2025
$5.1MTraining in Mechanisms and Clinical Presentation of PainT32NS073548 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jami Lynn Saloman, BRADLEY K. TAYLOR · 2012 to 2026
$3.1MDorsal horn circuits for mechanical allodyniaR01NS107364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2019 to 2022
$2.1MCentral Circuits for Mechanical PainR56NS104964 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2018 to 2018
$543kMolecular and functional organization of the dorsal horn in mouse and non-human primateR21NS109792 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2018 to 2019
$413kStudy of the Cholesystokinin (CCK) Molecular Subsets in the Mouse and Macaque Dorsal HornF31NS111791 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AROKIARAJ, CYNTHIA MARY · 2019 to 2020
$91kNIAMS NIH HHS R01 AR063772NINDS NIH HHS F31 NS111791NINDS NIH HHS R01 NS096705NINDS NIH HHS R01 NS107364NINDS NIH HHS R21 NS109792NINDS NIH HHS R35 NS111643NINDS NIH HHS R56 NS104964NINDS NIH HHS T32 NS007433NINDS NIH HHS T32 NS073548
Abstract
The spinal dorsal horn is a major site for the induction and maintenance of mechanical allodynia, but the circuitry that underlies this clinically important form of pain remains unclear. The studies presented here provide strong evidence that the neural circuits conveying mechanical allodynia in the dorsal horn differ by the nature of the injury. Calretinin (CR) neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, while protein kinase C gamma (PKCγ) neurons at the lamina II/III border convey mechanical allodynia induced by neuropathic injuries. Cholecystokinin (CCK) neurons located deeper within the dorsal horn (laminae III-IV) are important for both types of injuries. Interestingly, the Maf
Indexed as
Amino Acid Transport Systems, AcidicAnimalsFemaleHyperalgesiaMaleMiceMice, Inbred C57BLMice, TransgenicNerve NetPain MeasurementSpinal Cord Dorsal HornSpinal Cord InjuriesAmino Acid Transport Systems, AcidicSlc17a8 protein, mousecalretinincholecystokinindorsal horninflammatory painmechanical allodynianeural circuitryneuropathic painpainprotein kinase C gammavesicular glutamate transporter 3
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