ArticleClinical and experimental pediatrics2021
Food allergies and food-induced anaphylaxis: role of cofactors.
Article in Clinical and experimental pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Military Standards for Anaphylaxis: Aligning Allergy Science, Operational Risk, and Waiver Documentation.Current allergy and asthma reports · 2026Review
- Unusual Causes of Food-Induced Anaphylaxis - A Review.Indian dermatology online journal · 2026Article
- A Review of Walnut Allergy: Allergens Characteristic, the Impact of Processing on Allergenicity and Future Perspectives.Foods (Basel, Switzerland) · 2026Review
- Biomarker Research in NSAID Hypersensitivity: A Scoping Review and Evidence Map.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Asthma and Multi-Food Allergy Are Risk Factors for Oral Food Challenge Failure-A Single-Center Experience.Nutrients · 2025Article
- Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models.Foods (Basel, Switzerland) · 2025Review
- Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs.Frontiers in toxicology · 2025Review
- Cofactor-enhanced food allergy to presumed soy storage proteins in a pediatric patient.Einstein (Sao Paulo, Brazil) · 2025Article
- Anaphylaxis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Review
- Identifying patients at risk of anaphylaxis.The World Allergy Organization journal · 2024Review
- Cow's milk and hen's egg anaphylaxis: A comprehensive data analysis from the European Anaphylaxis Registry.Clinical and translational allergy · 2023Article
- Dietary Factors May Delay Tolerance Acquisition in Food Protein-Induced Allergic Proctocolitis.Nutrients · 2023Observational
- Blueberry (Journal of asthma and allergy · 2023Article
- Shrimp sensitization in house dust mite algerian allergic patients: A single center experience.The World Allergy Organization journal · 2022Article
- Patterns of Clinical Reactivity in a Danish Cohort of Tree Nut Allergic Children, Adolescents, and Young Adults.Frontiers in allergy · 2022Article
- Acute Urticaria and Anaphylaxis: Differences and Similarities in Clinical Management.Frontiers in allergy · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Food allergies and food-induced anaphylaxis are important health problems. Several cofactors modulating the onset of anaphylaxis have been identified. In the presence of cofactors, allergic reactions may be induced at lower doses of food allergens and/or become severe. Exercise and concomitant infections are well-documented cofactors of anaphylaxis in children. Other factors such as consumption of nonsteroidal anti-inflammatory drugs, alcohol ingestion, and stress have been reported. Cofactors reportedly play a role in approximately 30% of anaphylactic reactions in adults and 14%-18.3% in children. Food-dependent exercise-induced anaphylaxis (FDEIA) is the best-studied model of cofactor-induced anaphylaxis. Wheat-dependent exercise-induced anaphylaxis, the most common FDEIA condition, has been studied the most. The mechanisms of action of cofactors have not yet been fully identified. This review aims to educate clinicians on recent developments in the role of cofactors and highlight the importance of recognizing cofactors in food allergies and food-induced anaphylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.