ArticleThe Journal of clinical endocrinology and metabolism2021
Surgical Outcomes Among Primary Aldosteronism Patients Without Visible Adrenal Lesions.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Optimising patient selection for adrenal vein sampling in primary aldosteronism: role of biochemical markers and scoring systems.Endocrine · 2026Article
- Optimizing the diagnosis of primary aldosteronism: The role of adrenal vein sampling and the need for high-expertise reference centers.Journal of neuroendocrinology · 2026Observational
- Multiple radiologist review of adrenal CT still frequently misses lateralized surgical primary aldosteronism.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism.American journal of hypertension · 2022Article
- How to Explore an Endocrine Cause of Hypertension.Journal of clinical medicine · 2022Review
- Should Adrenal Venous Sampling Be Performed in PA Patients Without Apparent Adrenal Tumors?Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
contextMany patients with unilateral primary aldosteronism (PA) have normal adrenal imaging, but little is known about their outcome following adrenalectomy.
objectiveTo evaluate biochemical and clinical outcomes after adrenalectomy in patients with unilateral PA and normal-appearing adrenal imaging.
designRetrospective cohort study of patients seen between January 2006 and May 2018.
settingA Canadian tertiary care PA referral center. PATIENTS: Consecutive individuals with PA, normal cross-sectional adrenal imaging, and lateralizing adrenal vein sampling (AVS) who underwent adrenalectomy during the study period. PRIMARY OUTCOME: Biochemical response to adrenalectomy graded according to the Primary Aldosteronism Surgical Outcome criteria.
resultsA total of 40 patients were included. Biochemical outcomes were available for 33 people (mean age, 54.7 years; 91% male; median follow-up, 2.7 months), with 28 (85%) showing a complete or partial response and 5 (15%) with no response. Clinical outcomes were available for 36 people (mean age, 54.6 years; 86% male; median follow-up, 9.8 months), with 31 (86%) demonstrating a complete or partial response and 5 (14%) with no response.
conclusionsThe prognosis after adrenalectomy is highly favorable for patients with unilateral PA and normal-appearing adrenal imaging. Patients with lateralizing disease should be considered for surgery despite apparently normal adrenal imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.